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Cesarean section does not increase the prevalence of allergic disease within 3 years of age in the offsprings

 Hye In Kim  ;  SeonMi Nam  ;  Yejin Park  ;  Yun Ji Jung  ;  Ha Yan Kim  ;  Kyung Won Kim  ;  Myung Hyun Sohn  ;  Young-Han Kim  ;  Joon-Ho Lee  ;  Soo Jong Hong  ;  Ja-Young Kwon 
 Obstetrics & Gynecology Science, Vol.62(1) : 11-18, 2019 
Journal Title
Obstetrics & Gynecology Science
Issue Date
Allergic disease ; Cesarean section ; Infant ; Labor
Objective: In this study, we evaluated the prevalence of allergic disease in offsprings delivered via the delivery modes of vaginal delivery vs. planned Cesarean section vs. Cesarean section with labor.

Methods: This study included 175 mother-neonate pairs from Severance Hospital who were enrolled in the Cohort for Childhood Origin of Asthma and allergic diseases study. Information regarding prenatal environmental factors, delivery, and diagnosis of allergic diseases was obtained from a questionnaire and medical record review. Patients with at least 3 years of follow-up data were included in this study. Results were adjusted for sex, birth weight, gestational age at birth, season of birth, neonatal intensive care unit admission, parity, breastfeeding, and maternal factors.

Results: A total of 175 offsprings were eligible for analysis. Among the subjects, 52.0% were delivered by vaginal delivery, 34.3% by planned Cesarean section, and 16.6% by Cesarean section with labor. Fifty-nine offsprings (33.7%) were diagnosed with allergic disease at a median age of 1 year (range 0.5-3 years). The prevalence of allergic disease was not associated with delivery mode after adjusting for confounding variables. Time period from membrane rupture to delivery, duration of the active phase, and the beginning of the pelvic division prior to Cesarean section were not associated with allergic disease development in offsprings.

Conclusion: Cesarean section, irrespective of the occurrence of labor before surgery, did not increase the prevalence of allergic disease in infants up to 3 years of age.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Kim, Ha Yan(김하얀)
Kim, Hye In(김혜인) ORCID logo https://orcid.org/0000-0001-7961-5988
Park, Yejin(박예진) ORCID logo https://orcid.org/0000-0002-0545-7267
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Joon Ho(이준호)
Jung, Yun Ji(정윤지) ORCID logo https://orcid.org/0000-0001-6615-6401
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