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Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers

Authors
 Eunhyang Park  ;  Yoon-La Choi  ;  Myung-Ju Ahn  ;  Joungho Han 
Citation
 Pathology Research and Practice, Vol.215(7) : 152441, 2019 
Journal Title
 Pathology Research and Practice 
ISSN
 0344-0338 
Issue Date
2019
Keywords
FISH ; Histology ; Immunohistochemistry ; Lung adenocarcinoma ; Non-small cell lung cancer (NSCLC) ; ROS1
Abstract
BACKGROUND: ROS1 rearrangement accounts for 1%-2% of non-small cell lung cancer (NSCLC) with a remarkable response to crizotinib. Although ROS1-rearranged tumors are known to have characteristic histologic features, only a few studies have investigated the histologic features of advanced-stage ROS1-rearranged tumors. METHODS: We analyzed the histopathologic features of ROS1-rearranged tumors in advanced-stage NSCLC patients and assessed the ROS1 immunohistochemistry (IHC) staining patterns of ROS1-rearranged cases. RESULTS: A total of 37 ROS1 fluorescence in situ hybridization (FISH)-positive cases and 64 ROS1 FISH-negative cases were analyzed, and all tumors were EGFR-, ALK-, and RET-negative. Solid pattern, round nuclei with macronucleoli, solid signet-ring cells, extracellular mucin, and a close relation with adjacent bronchioles were significantly associated with ROS1 rearrangement, and the solid signet-ring cell feature was exclusively identified in ROS1-rearranged tumors. ROS1 IHC showed a 97.3% sensitivity when weak to strong protein expression was considered positive. CONCLUSIONS: Our findings highlight distinct histologic features of ROS1-rearranged tumors, including their nuclear features. A thorough understanding of ROS1 rearrangement-related histologic features would be helpful to identify ROS1-rearranged tumors in advanced-stage NSCLC.
Full Text
https://www.sciencedirect.com/science/article/pii/S0344033819303292
DOI
10.1016/j.prp.2019.152441
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Eunhyang(박은향) ORCID logo https://orcid.org/0000-0003-2658-5054
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170902
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