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Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers

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dc.contributor.author박은향-
dc.date.accessioned2019-09-20T07:26:51Z-
dc.date.available2019-09-20T07:26:51Z-
dc.date.issued2019-
dc.identifier.issn0344-0338-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170902-
dc.description.abstractBACKGROUND: ROS1 rearrangement accounts for 1%-2% of non-small cell lung cancer (NSCLC) with a remarkable response to crizotinib. Although ROS1-rearranged tumors are known to have characteristic histologic features, only a few studies have investigated the histologic features of advanced-stage ROS1-rearranged tumors. METHODS: We analyzed the histopathologic features of ROS1-rearranged tumors in advanced-stage NSCLC patients and assessed the ROS1 immunohistochemistry (IHC) staining patterns of ROS1-rearranged cases. RESULTS: A total of 37 ROS1 fluorescence in situ hybridization (FISH)-positive cases and 64 ROS1 FISH-negative cases were analyzed, and all tumors were EGFR-, ALK-, and RET-negative. Solid pattern, round nuclei with macronucleoli, solid signet-ring cells, extracellular mucin, and a close relation with adjacent bronchioles were significantly associated with ROS1 rearrangement, and the solid signet-ring cell feature was exclusively identified in ROS1-rearranged tumors. ROS1 IHC showed a 97.3% sensitivity when weak to strong protein expression was considered positive. CONCLUSIONS: Our findings highlight distinct histologic features of ROS1-rearranged tumors, including their nuclear features. A thorough understanding of ROS1 rearrangement-related histologic features would be helpful to identify ROS1-rearranged tumors in advanced-stage NSCLC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, German, French, English(Summary), German(Summary)-
dc.publisherGustav Fischer Verlag-
dc.relation.isPartOfPathology Research and Practice-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHistopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorEunhyang Park-
dc.contributor.googleauthorYoon-La Choi-
dc.contributor.googleauthorMyung-Ju Ahn-
dc.contributor.googleauthorJoungho Han-
dc.identifier.doi10.1016/j.prp.2019.152441-
dc.contributor.localIdA05760-
dc.relation.journalcodeJ02474-
dc.identifier.eissn1618-0631-
dc.identifier.pmid31085007-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0344033819303292-
dc.subject.keywordFISH-
dc.subject.keywordHistology-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordLung adenocarcinoma-
dc.subject.keywordNon-small cell lung cancer (NSCLC)-
dc.subject.keywordROS1-
dc.contributor.alternativeNamePark, Eunhyang-
dc.contributor.affiliatedAuthor박은향-
dc.citation.volume215-
dc.citation.number7-
dc.citation.startPage152441-
dc.identifier.bibliographicCitationPathology Research and Practice, Vol.215(7) : 152441, 2019-
dc.identifier.rimsid64120-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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