Cited 13 times in
Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers
DC Field | Value | Language |
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dc.contributor.author | 박은향 | - |
dc.date.accessioned | 2019-09-20T07:26:51Z | - |
dc.date.available | 2019-09-20T07:26:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170902 | - |
dc.description.abstract | BACKGROUND: ROS1 rearrangement accounts for 1%-2% of non-small cell lung cancer (NSCLC) with a remarkable response to crizotinib. Although ROS1-rearranged tumors are known to have characteristic histologic features, only a few studies have investigated the histologic features of advanced-stage ROS1-rearranged tumors. METHODS: We analyzed the histopathologic features of ROS1-rearranged tumors in advanced-stage NSCLC patients and assessed the ROS1 immunohistochemistry (IHC) staining patterns of ROS1-rearranged cases. RESULTS: A total of 37 ROS1 fluorescence in situ hybridization (FISH)-positive cases and 64 ROS1 FISH-negative cases were analyzed, and all tumors were EGFR-, ALK-, and RET-negative. Solid pattern, round nuclei with macronucleoli, solid signet-ring cells, extracellular mucin, and a close relation with adjacent bronchioles were significantly associated with ROS1 rearrangement, and the solid signet-ring cell feature was exclusively identified in ROS1-rearranged tumors. ROS1 IHC showed a 97.3% sensitivity when weak to strong protein expression was considered positive. CONCLUSIONS: Our findings highlight distinct histologic features of ROS1-rearranged tumors, including their nuclear features. A thorough understanding of ROS1 rearrangement-related histologic features would be helpful to identify ROS1-rearranged tumors in advanced-stage NSCLC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German, French, English(Summary), German(Summary) | - |
dc.publisher | Gustav Fischer Verlag | - |
dc.relation.isPartOf | Pathology Research and Practice | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell lung cancers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Eunhyang Park | - |
dc.contributor.googleauthor | Yoon-La Choi | - |
dc.contributor.googleauthor | Myung-Ju Ahn | - |
dc.contributor.googleauthor | Joungho Han | - |
dc.identifier.doi | 10.1016/j.prp.2019.152441 | - |
dc.contributor.localId | A05760 | - |
dc.relation.journalcode | J02474 | - |
dc.identifier.eissn | 1618-0631 | - |
dc.identifier.pmid | 31085007 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0344033819303292 | - |
dc.subject.keyword | FISH | - |
dc.subject.keyword | Histology | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Lung adenocarcinoma | - |
dc.subject.keyword | Non-small cell lung cancer (NSCLC) | - |
dc.subject.keyword | ROS1 | - |
dc.contributor.alternativeName | Park, Eunhyang | - |
dc.contributor.affiliatedAuthor | 박은향 | - |
dc.citation.volume | 215 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 152441 | - |
dc.identifier.bibliographicCitation | Pathology Research and Practice, Vol.215(7) : 152441, 2019 | - |
dc.identifier.rimsid | 64120 | - |
dc.type.rims | ART | - |
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