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Distinct Clinical Courses of Epithelial Ovarian Cancer with Mutations in BRCA1 5' and 3' Exons

Authors
 KYUNG JIN EOH  ;  HYUNG SEOK PARK  ;  JI SOO PARK  ;  SEUNG-TAE LEE  ;  JUNG WOO HAN  ;  JUNG-YUN LEE  ;  SUNGHOON KIM  ;  SANG WUN KIM  ;  YOUNG TAE KIM  ;  EUN JI NAM 
Citation
 Anticancer Research, Vol.38(12) : 6947-6953, 2018 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2018
MeSH
• 3' Flanking Region/genetics ; 5' Flanking Region/genetics ; Adult ; Aged ; BRCA1 Protein/genetics* ; Carcinoma, Ovarian Epithelial/genetics* ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/pathology ; Disease Progression ; Exons/genetics ; Female ; Follow-Up Studies ; Genes, BRCA1 ; Humans ; Middle Aged ; Mutation* ; Ovarian Neoplasms/genetics* ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Retrospective Studies ; Survival Analysis
Keywords
BRCA1 ; epithelial ovarian cancer ; exon ; prognosis
Abstract
BACKGROUND/AIM: This study aimed to determine the effect of different BRCA1 exonal mutations on the clinical course of epithelial ovarian cancer (EOC). PATIENTS AND METHODS: Clinicopathological variables and survival outcomes were compared among 53 primary EOC patients with pathogenic BRCA1 mutations in exons 1-11 (5' mutations) and in exons 12-24 (3' mutations). RESULTS: BRCA1 5' exonal mutations were found in 35 (66.0%) patients. The median follow-up period was 40 months. Clinicopathological variables remained unchanged between the two groups. Patients with 5' mutations had a significantly longer progression-free survival than those with C-terminal mutations (p=0.034), better predicting progression-free survival [2.923 (1.402-6.093), p=0.004], but not overall survival in cases of multiple relapses (p=0.497). CONCLUSION: N-terminal BRCA1 mutations in EOC patients are associated with favourable primary progression-free survival, a trend observed only in primary progression-free survival, not in overall survival.
Full Text
http://ar.iiarjournals.org/content/38/12/6947.long
DOI
10.21873/anticanres.13073
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Nam, Eun Ji(남은지)
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Eoh, Kyung Jin(어경진) ORCID logo https://orcid.org/0000-0002-1684-2267
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
Lee, Jung-Yun(이정윤) ORCID logo https://orcid.org/0000-0001-7948-1350
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170860
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