Cited 5 times in
Distinct Clinical Courses of Epithelial Ovarian Cancer with Mutations in BRCA1 5' and 3' Exons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 어경진 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 이정윤 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 박지수 | - |
dc.date.accessioned | 2019-09-20T07:22:51Z | - |
dc.date.available | 2019-09-20T07:22:51Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170860 | - |
dc.description.abstract | BACKGROUND/AIM: This study aimed to determine the effect of different BRCA1 exonal mutations on the clinical course of epithelial ovarian cancer (EOC). PATIENTS AND METHODS: Clinicopathological variables and survival outcomes were compared among 53 primary EOC patients with pathogenic BRCA1 mutations in exons 1-11 (5' mutations) and in exons 12-24 (3' mutations). RESULTS: BRCA1 5' exonal mutations were found in 35 (66.0%) patients. The median follow-up period was 40 months. Clinicopathological variables remained unchanged between the two groups. Patients with 5' mutations had a significantly longer progression-free survival than those with C-terminal mutations (p=0.034), better predicting progression-free survival [2.923 (1.402-6.093), p=0.004], but not overall survival in cases of multiple relapses (p=0.497). CONCLUSION: N-terminal BRCA1 mutations in EOC patients are associated with favourable primary progression-free survival, a trend observed only in primary progression-free survival, not in overall survival. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | Anticancer Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | • 3' Flanking Region/genetics | - |
dc.subject.MESH | 5' Flanking Region/genetics | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | BRCA1 Protein/genetics* | - |
dc.subject.MESH | Carcinoma, Ovarian Epithelial/genetics* | - |
dc.subject.MESH | Carcinoma, Ovarian Epithelial/mortality | - |
dc.subject.MESH | Carcinoma, Ovarian Epithelial/pathology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Exons/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Genes, BRCA1 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Ovarian Neoplasms/genetics* | - |
dc.subject.MESH | Ovarian Neoplasms/mortality | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Distinct Clinical Courses of Epithelial Ovarian Cancer with Mutations in BRCA1 5' and 3' Exons | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | KYUNG JIN EOH | - |
dc.contributor.googleauthor | HYUNG SEOK PARK | - |
dc.contributor.googleauthor | JI SOO PARK | - |
dc.contributor.googleauthor | SEUNG-TAE LEE | - |
dc.contributor.googleauthor | JUNG WOO HAN | - |
dc.contributor.googleauthor | JUNG-YUN LEE | - |
dc.contributor.googleauthor | SUNGHOON KIM | - |
dc.contributor.googleauthor | SANG WUN KIM | - |
dc.contributor.googleauthor | YOUNG TAE KIM | - |
dc.contributor.googleauthor | EUN JI NAM | - |
dc.identifier.doi | 10.21873/anticanres.13073 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A04842 | - |
dc.contributor.localId | A04627 | - |
dc.contributor.localId | A04638 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 30504414 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/38/12/6947.long | - |
dc.subject.keyword | BRCA1 | - |
dc.subject.keyword | epithelial ovarian cancer | - |
dc.subject.keyword | exon | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | 김상운 | - |
dc.contributor.affiliatedAuthor | 김성훈 | - |
dc.contributor.affiliatedAuthor | 김영태 | - |
dc.contributor.affiliatedAuthor | 남은지 | - |
dc.contributor.affiliatedAuthor | 박형석 | - |
dc.contributor.affiliatedAuthor | 어경진 | - |
dc.contributor.affiliatedAuthor | 이승태 | - |
dc.contributor.affiliatedAuthor | 이정윤 | - |
dc.contributor.affiliatedAuthor | 한정우 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 6947 | - |
dc.citation.endPage | 6953 | - |
dc.identifier.bibliographicCitation | Anticancer Research, Vol.38(12) : 6947-6953, 2018 | - |
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