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Mitochondrial tumor suppressor 1 is a target of AT-rich interactive domain 1A and progesterone receptor in the murine uterus

Authors
 Hye Jin Chang  ;  Hanna E. Teasley  ;  Jung-Yoon Yoo  ;  Tae Hoon Kim  ;  Jae-Wook Jeong 
Citation
 Asian-Australasian Journal of Animal Sciences, Vol.31(8) : 1176-1182, 2018 
Journal Title
 Asian-Australasian Journal of Animal Sciences 
ISSN
 1011-2367 
Issue Date
2018
Keywords
AT-rich Interactive Domain 1A (ARID1A) ; Estrogen ; Progesterone Receptor ; Uterus ; Mitochondrial Tumor Suppressor 1 (MTUS1)
Abstract
Objective: Progesterone receptor (PGR) and AT-rich interactive domain 1A (ARID1A) have important roles in the establishment and maintenance of pregnancy in the uterus. In present studies, we examined the expression of mitochondrial tumor suppressor 1 (MTUS1) in the murine uterus during early pregnancy as well as in response to ovarian steroid hormone treatment. METHODS: We performed quantitative reverse transcription polymerase chain reaction and immunohistochemistry analysis to investigate the regulation of MTUS1 by ARID1A and determined expression patterns of MTUS1 in the uterus during early pregnancy. RESULTS: The expression of MTUS1 was detected on day 0.5 of gestation (GD 0.5) and then gradually increased until GD 3.5 in the luminal and glandular epithelium. However, the expression of MTUS1 was significantly reduced in the uterine epithelial cells of Pgrcre/+Arid1af/f and Pgr knockout (PRKO) mice at GD 3.5. Furthermore, MTUS1 expression was remarkably induced after P4 treatment in the luminal and glandular epithelium of the wild-type mice. However, the induction of MTUS1 expression was not detected in uteri of Pgrcre/+Arid1af/f or PRKO mice treated with P4. CONCLUSION: These results suggest that MTUS1 is a novel target gene by ARID1A and PGR in the uterine epithelial cells.
Files in This Item:
T201806058.pdf Download
DOI
10.5713/ajas.18.0011
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Yoo, Jung Yoon(유정윤) ORCID logo https://orcid.org/0000-0001-9366-3863
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170859
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