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Mitochondrial tumor suppressor 1 is a target of AT-rich interactive domain 1A and progesterone receptor in the murine uterus

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dc.contributor.author유정윤-
dc.date.accessioned2019-09-20T07:22:48Z-
dc.date.available2019-09-20T07:22:48Z-
dc.date.issued2018-
dc.identifier.issn1011-2367-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170859-
dc.description.abstractObjective: Progesterone receptor (PGR) and AT-rich interactive domain 1A (ARID1A) have important roles in the establishment and maintenance of pregnancy in the uterus. In present studies, we examined the expression of mitochondrial tumor suppressor 1 (MTUS1) in the murine uterus during early pregnancy as well as in response to ovarian steroid hormone treatment. METHODS: We performed quantitative reverse transcription polymerase chain reaction and immunohistochemistry analysis to investigate the regulation of MTUS1 by ARID1A and determined expression patterns of MTUS1 in the uterus during early pregnancy. RESULTS: The expression of MTUS1 was detected on day 0.5 of gestation (GD 0.5) and then gradually increased until GD 3.5 in the luminal and glandular epithelium. However, the expression of MTUS1 was significantly reduced in the uterine epithelial cells of Pgrcre/+Arid1af/f and Pgr knockout (PRKO) mice at GD 3.5. Furthermore, MTUS1 expression was remarkably induced after P4 treatment in the luminal and glandular epithelium of the wild-type mice. However, the induction of MTUS1 expression was not detected in uteri of Pgrcre/+Arid1af/f or PRKO mice treated with P4. CONCLUSION: These results suggest that MTUS1 is a novel target gene by ARID1A and PGR in the uterine epithelial cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAsian-Australasian Association of Animal Production-
dc.relation.isPartOfAsian-Australasian Journal of Animal Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMitochondrial tumor suppressor 1 is a target of AT-rich interactive domain 1A and progesterone receptor in the murine uterus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorHye Jin Chang-
dc.contributor.googleauthorHanna E. Teasley-
dc.contributor.googleauthorJung-Yoon Yoo-
dc.contributor.googleauthorTae Hoon Kim-
dc.contributor.googleauthorJae-Wook Jeong-
dc.identifier.doi10.5713/ajas.18.0011-
dc.contributor.localIdA02502-
dc.relation.journalcodeJ03645-
dc.identifier.eissn1976-5517-
dc.identifier.pmid29642667-
dc.subject.keywordAT-rich Interactive Domain 1A (ARID1A)-
dc.subject.keywordEstrogen-
dc.subject.keywordProgesterone Receptor-
dc.subject.keywordUterus-
dc.subject.keywordMitochondrial Tumor Suppressor 1 (MTUS1)-
dc.contributor.alternativeNameYoo, Jung Yoon-
dc.contributor.affiliatedAuthor유정윤-
dc.citation.volume31-
dc.citation.number8-
dc.citation.startPage1176-
dc.citation.endPage1182-
dc.identifier.bibliographicCitationAsian-Australasian Journal of Animal Sciences, Vol.31(8) : 1176-1182, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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