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Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy

 Ki-Bum Won  ;  Sang-Eun Lee  ;  Byoung Kwon Lee  ;  Hyung-Bok Park  ;  Ran Heo  ;  Asim Rizvi  ;  Fay Y. Lin  ;  Amit Kumar  ;  Martin Hadamitzky  ;  Yong-Jin Kim  ;  Ji Min Sung  ;  Edoardo Conte  ;  Daniele Andreini  ;  Gianluca Pontone  ;  Matthew J. Budoff  ;  Ilan Gottlieb  ;  Eun Ju Chun  ;  Filippo Cademartiri  ;  Erica Maffei  ;  Hugo Marques  ;  Jonathon A. Leipsic  ;  Sanghoon Shin  ;  Jung Hyun Choi  ;  Renu Virmani  ;  Habib Samady  ;  Kavitha Chinnaiyan  ;  Gilbert L. Raff  ;  Peter H. Stone  ;  Daniel S. Berman  ;  Jagat Narula  ;  Leslee J. Shaw  ;  Jeroen J. Bax  ;  James K. Min  ;  Hyuk-Jae Chang 
 Journal of Cardiovascular Computed Tomography, Vol.13(2) : 142-147, 2019 
Journal Title
 Journal of Cardiovascular Computed Tomography 
Issue Date
Aged ; Biomarkers/metabolism ; Blood Glucose/metabolism* ; Computed Tomography Angiography* ; Coronary Angiography/methods* ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging* ; Coronary Artery Disease/pathology ; Coronary Vessels/diagnostic imaging* ; Coronary Vessels/pathology ; Diabetes Mellitus/blood* ; Diabetes Mellitus/diagnosis ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Plaque, Atherosclerotic* ; Prediabetic State/blood ; Prediabetic State/diagnosis ; Predictive Value of Tests ; Prognosis ; Registries ; Risk Factors ; Time Factors
Coronary atherosclerosis ; Coronary computed tomography angiography ; Pre-diabetes
BACKGROUND: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). METHODS: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). RESULTS: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010). CONCLUSION: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. CLINICAL TRIAL REGISTRATION: ClinicalTrials.govNCT02803411.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Sung, Ji Min(성지민)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Heo, Ran(허란)
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