Cited 8 times in
Phase II trial of preoperative sequential chemotherapy followed by chemoradiotherapy for high-risk gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 강버들 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김은혜 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 범승훈 | - |
dc.contributor.author | 손태일 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정인경 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 정현수 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 형우진 | - |
dc.date.accessioned | 2019-07-29T05:21:27Z | - |
dc.date.available | 2019-07-29T05:21:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170462 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: To evaluate the safety and efficacy of preoperative chemotherapy (CTx) followed by chemoradiotherapy (CCRT) for high-risk gastric cancer (GC). METHODS AND MATERIALS: The inclusion criteria were as follows: (1) Borrmann type 4; (2) large Borrmann type 3 (≥8 cm); (3) single bulky (≥3 cm × 1) or multiple lymph nodes (≥1.5 cm × 3). Patients received two 21-day courses of induction CTx of TS-1 (35 mg/m2, p.o, twice daily on days 1-14), docetaxel (30 mg/m2, i.v., days 1 and 8), and cisplatin (30 mg/m2, i.v., days 1 and 8) followed by CCRT (two courses of TS-1 and cisplatin in combination with 45 Gy radiation). RESULTS: Forty-two patients were enrolled between March 2014 and February 2016, and 39 of these completed sequential CTx and CCRT. Among the 33 patients who underwent R0 resection, the pathologic response rate was 39.4% [no residual carcinoma (n = 5, 15.2%), with 1-10% residual carcinoma (n = 8, 24.2%)]. Overall, 4 patients (12.1%) were pathologic stage 0, 7 (21.2%) were stage I, 10 (30.3%) were stage II, and 12 (36.4%) were stage III. The overall survival rate at 3 years was 77.9% for stages 0 and I, 66.8% for stages II-III, and 33.3% for unresectable cases (P = 0.001). Toxicity was mild to moderate with grade 4 neutropenia (n = 1) and neutropenic fever (n = 1) as the most prominent side-effects. CONCLUSIONS: Sequential CTx and CCRT prior to surgery are feasible and effective for high-risk GC. TRIAL REGISTRATION NUMBER: NCT02495493. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Phase II trial of preoperative sequential chemotherapy followed by chemoradiotherapy for high-risk gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Song-Ee Baek | - |
dc.contributor.googleauthor | Hyoung-Il Kim | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Seung-Hoon Beom | - |
dc.contributor.googleauthor | Beodeul Kang | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Taeil Son | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Eun Hye Kim | - |
dc.contributor.googleauthor | Jun Chul Park | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Su-Jin Shin | - |
dc.contributor.googleauthor | Hyunsoo Chung | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1016/j.radonc.2019.06.029 | - |
dc.contributor.localId | A00029 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00827 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A04581 | - |
dc.contributor.localId | A01998 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03693 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03765 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J02597 | - |
dc.identifier.eissn | 1879-0887 | - |
dc.identifier.pmid | 31302344 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S016781401932969X | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Preoperative chemoradiotherapy | - |
dc.subject.keyword | Preoperative chemotherapy | - |
dc.contributor.alternativeName | Kang, Beo Deul | - |
dc.contributor.affiliatedAuthor | 강버들 | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김은혜 | - |
dc.contributor.affiliatedAuthor | 김현기 | - |
dc.contributor.affiliatedAuthor | 김형일 | - |
dc.contributor.affiliatedAuthor | 김효송 | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 박준철 | - |
dc.contributor.affiliatedAuthor | 범승훈 | - |
dc.contributor.affiliatedAuthor | 손태일 | - |
dc.contributor.affiliatedAuthor | 신성관 | - |
dc.contributor.affiliatedAuthor | 이상길 | - |
dc.contributor.affiliatedAuthor | 이용찬 | - |
dc.contributor.affiliatedAuthor | 임준석 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.contributor.affiliatedAuthor | 정민규 | - |
dc.contributor.affiliatedAuthor | 정인경 | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.contributor.affiliatedAuthor | 정현수 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.contributor.affiliatedAuthor | 최윤영 | - |
dc.contributor.affiliatedAuthor | 형우진 | - |
dc.citation.volume | 140 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 149 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, Vol.140 : 143-149, 2019 | - |
dc.identifier.rimsid | 62954 | - |
dc.type.rims | ART | - |
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