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Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans

Authors
 Bon San Koo  ;  Yoonah Song  ;  Seunghun Lee  ;  Yoon‐Kyoung Sung  ;  Kyoung‐Jin Shin  ;  Nam H. Cho  ;  Jae‐Bum Jun 
Citation
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.22(3) : 411-416, 2019 
Journal Title
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 
ISSN
 1756-1841 
Issue Date
2019
Keywords
Korea ;  mitochondrial DNA ;  osteoarthritis ;  osteoarthritis of knee ; scoring methods
Abstract
AIM: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA). METHODS: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). The frequency of the mtDNA haplogroup was compared between participants with knee OA (K/L score ≥2 or total knee replacement arthroplasty [OA group]) and those without knee OA (K/L < 2 [control group]) at the 6th follow-up. Multiple logistic regression was used to determine the relative risk (RR) of mtDNA haplogroups for OA by adjusting for sex, age, body mass index, smoking and metabolic syndrome. RESULTS: There were 1115 participants with epidemiological data, knee radiographs and DNA samples. Of these, 572 participants had a K/L score of 0 at the 2nd follow up, and 438 underwent knee radiography at the 6th follow up. Among the 438 participants, 160 were classified as having knee OA, and 278 were classified as the control group. The haplogroup B showed a significantly higher frequency in the OA group than in the control group (unadjusted RR = 1.794, P = 0.030; adjusted RR = 2.389, P = 0.004). CONCLUSION: Our data suggest that mtDNA haplogroup B contributed to the new development of knee OA in Koreans.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/1756-185X.13453
DOI
10.1111/1756-185X.13453
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170411
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