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Longitudinal quantitative assessment of coronary plaque progression related to body mass index using serial coronary computed tomography angiography

Authors
 Ki-Bum Won  ;  Sang-Eun Lee  ;  Byoung Kwon Lee  ;  Hyung-Bok Park  ;  Ran Heo  ;  Asim Rizvi Martin Hadamitzky  ;  Yong-Jin Kim  ;  Ji Min Sung  ;  Edoardo Conte  ;  Daniele Andreini  ;  Gianluca Pontone Matthew J. Budoff  ;  Ilan Gottlieb  ;  Eun Ju Chun  ;  Filippo Cademartiri  ;  Erica Maffei  ;  Hugo Marques Jonathon A. Leipsic  ;  Sanghoon Shin  ;  Jung Hyun Choi  ;  Renu Virmani  ;  Habib Samady  ;  Peter H. Stone Daniel S Berman  ;  Jagat Narula  ;  Leslee J. Shaw  ;  Jeroen J. Bax  ;  James K. Min  ;  Hyuk-Jae Chang 
Citation
 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.20(5) : 591-599, 2019 
Journal Title
 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING 
ISSN
 2047-2404 
Issue Date
2019
Keywords
atherosclerosis ;  body mass index ;  coronary computed tomography angiography ; obesity
Abstract
AIMS: This study explored the coronary plaque volume change (PVC) according to the change of percent body mass index (BMI) and categorical BMI group using serial coronary computed tomography angiography (CCTA). METHODS AND RESULTS: A total of 1568 subjects who underwent serial CCTA with available BMI at baseline (CCTA1) and follow-up (CCTA2) were included. Median inter-scan period was 3.3 (interquartile range: 2.6-4.6) years. Quantitative assessment of coronary plaque was performed at both scans. All participants were categorized into three BMI (kg/m2) groups: normal: <25.0; overweight: 25.0-29.9; and obesity: ≥30.0. During follow-up, there were no significant differences in annualized PVC according to the 5% change of BMI in all BMI groups. Among 1424 (90.8%) subjects in the same BMI group at CCTA1 and CCTA2, a significant difference in annualized (PVC) was observed among the three groups. In 144 (9.2%) subjects with the change in their BMI group at CCTA2 compared their results at CCTA1, annualized PVC was not different compared with subjects in the same BMI group during follow-up. The percent change of BMI was not significantly related to the annualized PVC after adjusting confounding factors. Male gender [odds ratio (OR): 1.38; 95% confidence interval (CI): 1.05-1.81; P = 0.022], baseline plaque volume (OR: 1.07; 95% CI: 1.05-1.09; P < 0.001), and baseline overweight or obesity (OR: 1.35; 95% CI: 1.04-1.77; P = 0.027) were independently associated with coronary plaque progression. CONCLUSION: Over the near term, longitudinal small changes in BMI were not associated with changes in coronary plaque volume although baseline BMI was. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02803411.
Full Text
https://academic.oup.com/ehjcimaging/article/20/5/591/5292476
DOI
10.1093/ehjci/jey192
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Sung, Ji Min(성지민)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Heo, Ran(허란)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170354
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