21 40

Cited 0 times in

The Effects of Transcranial Direct Current Stimulation on the Cognitive and Behavioral Changes After Electrode Implantation Surgery in Rats

 Jooyoung Oh  ;  Jinsil Ham  ;  Dongrae Cho  ;  Jin Young Park  ;  Jae-Jin Kim  ;  Boreom Lee 
 FRONTIERS IN PSYCHOLOGY, Vol.10 : 291, 2019 
Journal Title
Issue Date
brain stimulation ; connectivity ; delirium ; electrophysiology ; rat ;  transcranial direct currentstimulation
Postoperative delirium can lead to increased morbidity and mortality, and may even be a potentially life-threatening clinical syndrome. However, the neural mechanism underlying this condition has not been fully understood and there is little knowledge regarding potential preventive strategies. To date, investigation of transcranial direct current stimulation (tDCS) for the relief of symptoms caused by neuropsychiatric disorders and the enhancement of cognitive performance has led to promising results. In this study, we demonstrated that tDCS has a possible effect on the fast recovery from delirium in rats after microelectrode implant surgery, as demonstrated by postoperative behavior and neurophysiology compared with sham stimulation. This is the first study to describe the possible effects of tDCS for the fast recovery from delirium based on the study of both electroencephalography and behavioralchanges. Postoperative rats showed decreased attention, which is the core symptom of delirium. However, anodal tDCS over the right frontal area immediately after surgery exhibited positive effects on acute attentional deficit. It was found that relative power of theta was lower in the tDCS group than in the sham group after surgery, suggesting that the decrease might be the underlying reason for the positive effects of tDCS. Connectivity analysis revealed that tDCS could modulate effective connectivity and synchronization of brain activity among different brain areas, including the frontal cortex, parietal cortex, and thalamus. It was concluded that anodal tDCS on the right frontal regions may have the potential to help patients recover quickly from delirium.
Files in This Item:
T201902128.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Oh, Jooyoung(오주영) ORCID logo https://orcid.org/0000-0001-6721-399X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.