The Effects of Transcranial Direct Current Stimulation on the Cognitive and Behavioral Changes After Electrode Implantation Surgery in Rats

Abstract

Postoperative delirium can lead to increased morbidity and mortality, and may even be a potentially life-threatening clinical syndrome. However, the neural mechanism underlying this condition has not been fully understood and there is little knowledge regarding potential preventive strategies. To date, investigation oftranscranialdirectcurrentstimulation(tDCS) for the relief of symptoms caused by neuropsychiatric disorders and the enhancement ofcognitiveperformance has led to promising results. In this study, we demonstrated that tDCS has a possible effect on the fast recovery from delirium inratsaftermicroelectrode implantsurgery, as demonstrated by postoperative behavior and neurophysiology compared with shamstimulation. This is the first study to describe the possibleeffectsof tDCS for the fast recovery from delirium based on the study of both electroencephalography andbehavioralchanges. Postoperativeratsshowed decreased attention, which is the core symptom of delirium. However, anodal tDCS over the right frontal area immediatelyaftersurgeryexhibited positiveeffectson acute attentional deficit. It was found that relative power of theta was lower in the tDCS group than in the sham groupaftersurgery, suggesting that the decrease might be the underlying reason for the positiveeffectsof tDCS. Connectivity analysis revealed that tDCS could modulate effective connectivity and synchronization of brain activity among different brain areas, including the frontal cortex, parietal cortex, and thalamus. It was concluded that anodal tDCS on the right frontal regions may have the potential to help patients recover quickly from delirium.