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Relationship between serum alkaline phosphatase level, C-reactive protein and leukocyte counts in adults aged 60 years or older

Authors
 Min-Seok Seo  ;  Jae-Yong Shim  ;  Yong-Jae Lee 
Citation
 Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, Vol.79(4) : 233-237, 2019 
Journal Title
Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
ISSN
 0085-591X 
Issue Date
2019
Keywords
Alkaline phosphatase ; C-reactive protein ; cardiovascular disease ; inflammation ; leukocyte
Abstract
Serumalkaline phosphatase(ALP), a useful marker of hepatobiliary or bone disorders, has been known to be associated with cardiovascular disease (CVD), which is increasingly being viewed as an inflammatory disease.C-reactive proteinlevelandleukocyte counthave also been highlighted as independent risk markers of CVD. Thus, the mechanism underlying the link between elevated ALP and CVD could be subclinical low-grade inflammation. This study aimed to examine associations ofserumALPlevelwith inflammatory markers. This cross-sectional study included 2403 participants (1324 men and 1079 women)aged≥60yearswho participated in a health examination program.SerumALP quartiles were categorized as follows: Q1: ≤51, Q2: 52-61, Q3: 62-74 and Q4: ≥75 U/L. The odds ratios (ORs) and 95% confidence intervals (CIs) for high CRP andleukocyte count(≥75th percentiles) were calculated after adjusting for confounding variables acrossserumALP quartiles using multiple logistic regression analysis. Median CRPleveland meanleukocyte countincreased in accordance withserumALP quartiles. Compared to the lowest quartile, the ORs (95% CI) of the highest quartile for high CRP andleukocyte countwere 2.03 (1.50-2.76) and 1.54 (1.13-2.10) after adjusting for age, sex, body mass index, smoking status, alcohol intake, fasting plasma glucose, log-transformed triglyceride and HDL-cholesterollevels.SerumALPlevelwas positively and independently associated with inflammatory markers inadultsaged60yearsorolder.
Full Text
https://www.tandfonline.com/doi/full/10.1080/00365513.2019.1585567
DOI
10.1080/00365513.2019.1585567
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170338
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