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Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration

 Hao Yang Zhang  ;  Heng Bo Jiang  ;  Jeong-Hyun Ryu  ;  Hyojin Kang  ;  Kwang-Mahn Kim  ;  Jae-Sung Kwon 
 MATERIALS, Vol.12(10) : E1718, 2019 
Journal Title
Issue Date
3D printing ; artificial membranes ; biomaterials ; guided bone regeneration ; guided tissueregeneration ; polylactide
The aim of this study was to fabricate bioresorbable polylactide (PLA) membranes by 3D printing and compare theirpropertiesto those of the membranes fabricated by theconventionalmethod and compare the effect of different pore sizes on thepropertiesof the3D-printedmembranes.PLAmembranes with three different pore sizes (large pore-479 μm, small pore-273 μm, and no pore) were3D printed, and membranes fabricated using theconventionalsolvent casting method were used as the control group. Scanning electron microscopy (SEM) and micro-computed tomography (µ-CT) were taken to observe the morphology and obtain the porosity of the four groups. A tensile test was performed to compare the tensile strength, elastic modulus, and elongation at break of the membranes. Preosteoblast cells were cultured on the membranes for 1, 3 and 7 days, followed by a WST assay and SEM, to examine the cell proliferation on different groups. As a result, the3D-printedmembranes showed superior mechanicalpropertiesto those of the solvent cast membranes, and the3D-printedmembranes exhibited different advantageous mechanicalpropertiesdepending on the different pore sizes. The various fabrication methods and pore sizes did not have significantly different effects on cell growth. It is proven that 3D printing is a promising method for the fabrication of customized barrier membranes used in GBR/GTR.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyo Jin(강효진)
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
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