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Timing of extracorporeal shock wave therapy in rabbits with carpal tunnel syndrome

Authors
 Gi‐Young Park  ;  Dong Rak Kwon  ;  Sang Chul Lee 
Citation
 JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.13(6) : 1071-1078, 2019 
Journal Title
 JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1932-6254 
Issue Date
2019
Keywords
carpal tunnel syndrome ;  extracorporeal shock wave therapy ; injection ; median nerve ; rabbit
Abstract
The purpose of this study is to evaluate the effect of extracorporeal shock wave therapy(ESWT) according to treatment timing in rabbits with 10% dextrose-induced carpal tunnelsyndrome (CTS); 0.1-ml 10% dextrose solution was injected under ultrasound guidance twice weekly to the left forepaw subsynovial connective tissue (SSCT) within the carpal tunnel of 36 New Zealand white rabbits to induce CTS. The rabbits were randomly allocated into four groups: G1-S (sham ESWT), G2-E4 (ESWT at 4 weeks), G3-E8 (at 8 weeks), and G4-E16 (at 16 weeks). Radial ESWT (500 pulses, 0.08 mJ/mm2 , 2 Hz) was repeated thrice weekly. Median nerve distal motor latency (DML) was measured before injection and at 4, 8, 12, 16, and 20 weeks after the first injection. All rabbits were sacrificed 20 weeks after injection. The median nerve cross-sectional area (CSA) and SSCT thickness were measured with light microscopy. The mean median nerve DML at 4 weeks after the first dextrose injection did not differ from that at preinjection in all groups. The mean median nerve DML significantly increased before ESWT in all groups (p < .05); however, it did not increase in G2-E4 and G3-E8 for 12 weeks after ESWT and in G4-E16 for 4 weeks (p > .05). Mean CSA of the median nerve and mean SSCT thickness in G2-E4 were significantly lower than those in the other groups (p < .05). ESWT may prevent the progression of CTS for 12 weeks in rabbits with dextrose-induced CTS regardless of treatment timing, and early application results in superior outcomes.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/term.2862
DOI
10.1002/term.2862
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Chul(이상철) ORCID logo https://orcid.org/0000-0002-6241-7392
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170326
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