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Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea

Authors
 Wooyong Jeong  ;  In Young Jung  ;  Heun Choi  ;  Jung Ho Kim  ;  Hye Seong  ;  Jin Young Ahn  ;  Su Jin Jeong  ;  Nam Su Ku  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.35(2) : 213-216, 2019 
Journal Title
AIDS RESEARCH AND HUMAN RETROVIRUSES
ISSN
 0889-2229 
Issue Date
2019
Keywords
HIV ; integrasestrandtransferinhibitor ; resistancemutation ; transmittedresistance
Abstract
Updated guidelines for the treatment ofantiretroviraltherapy (ART)-negativepatientswithHIVrecommendintegrasestrandtransferinhibitor(INSTI)-based regimens.HIVpatientsare tested forresistanceto antiretrovirals, and the reported prevalence of transmitted INSTIresistanceremains rare worldwide. However, no data related to INSTIresistancein KoreanHIVpatientshave been reported. We aimed to determine the prevalence of INSTIresistance-relatedmutationsinSouthKorea. We subjected both ART-naive (n = 58) and ART-experienced KoreanHIVpatients(n = 41) to genotypicresistanceanalysis and determined a prevalence of INSTI majorresistancemutationsof 3.4% (n = 2) among ART-naivepatientsand 22.0% (n = 9) among ART-experiencedpatients. In the former group, both major INSTIresistancecases involved the nonpolymorphic E92Q mutation in theintegrasestrand. Our findings suggest that INSTIresistancetesting should be included in the standardresistancescreening protocols for KoreanHIVpatients.
Full Text
https://www.liebertpub.com/doi/abs/10.1089/AID.2018.0213
DOI
10.1089/AID.2018.0213
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Kim, June Myung(김준명)
Seong, Hye(성혜) ORCID logo https://orcid.org/0000-0002-5633-7214
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jeong, Wooyong(정우용)
Jung, In Young(정인영)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Heun(최흔) ORCID logo https://orcid.org/0000-0002-9622-9381
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170325
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