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Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea

Authors
 Wooyong Jeong  ;  In Young Jung  ;  Heun Choi  ;  Jung Ho Kim  ;  Hye Seong  ;  Jin Young Ahn  ;  Su Jin Jeong  ;  Nam Su Ku  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.35(2) : 213-216, 2019 
Journal Title
 AIDS RESEARCH AND HUMAN RETROVIRUSES 
ISSN
 0889-2229 
Issue Date
2019
Keywords
HIV ;  integrase strand transfer inhibitor ;  resistance mutation ; transmitted resistance
Abstract
Updated guidelines for the treatment of antiretroviral therapy (ART)-negative patients with HIVrecommend integrase strand transfer inhibitor (INSTI)-based regimens. HIV patients are tested for resistance to antiretrovirals, and the reported prevalence of transmitted INSTI resistance remains rare worldwide. However, no data related to INSTI resistance in Korean HIV patients have been reported. We aimed to determine the prevalence of INSTI resistance-related mutations in South Korea. We subjected both ART-naive (n = 58) and ART-experienced Korean HIV patients (n = 41) to genotypic resistance analysis and determined a prevalence of INSTI major resistance mutations of 3.4% (n = 2) among ART-naive patientsand 22.0% (n = 9) among ART-experienced patients. In the former group, both major INSTI resistance cases involved the nonpolymorphic E92Q mutation in the integrase strand. Our findings suggest that INSTI resistance testing should be included in the standard resistancescreening protocols for Korean HIV patients.
Full Text
https://www.liebertpub.com/doi/abs/10.1089/AID.2018.0213
DOI
10.1089/AID.2018.0213
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Jung Ho(김정호) ORCID logo https://orcid.org/0000-0002-5033-3482
Kim, June Myung(김준명)
Seong, Hye(성혜) ORCID logo https://orcid.org/0000-0002-5633-7214
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jeong, Wooyong(정우용)
Jung, In Young(정인영)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Heun(최흔) ORCID logo https://orcid.org/0000-0002-9622-9381
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170325
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