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Lacrimal Drainage Obstruction and Gastroesophageal Reflux Disease A Nationwide Longitudinal Cohort Study

Authors
 Tyler Hyungtaek Rim  ;  JaeSang Ko  ;  Sung Soo Kim  ;  Jin Sook Yoon 
Citation
 JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.53(4) : 277-283, 2019 
Journal Title
 JOURNAL OF CLINICAL GASTROENTEROLOGY 
ISSN
 0192-0790 
Issue Date
2019
Abstract
GOALS: This study aimed to evaluate the association between gastroesophageal reflux disease (GERD) and development of lacrimal drainage obstruction (LDO). BACKGROUND: It has been hypothesized that GERD may contribute toward the development of LDO. STUDY: This was a retrospective study of Koreans aged 40 to 79 years registered in the Korean National Health Screening Cohort from 2002 to 2013. Incident cases of LDO were identified according to the Korean Classification of Disease. We compared hazard ratios (HRs) for LDO between 22,570 patients with GERD and 112,850 patients without GERD by 1:5 propensity score-matched analysis. RESULTS: A total of 135,420 patients, representing 1,237,909 person-years, were evaluated. LDO developed in 1998 (8.9%) patients with GERD and 8565 (7.6%) patients without GERD (P<0.001). The incidence of LDO per 1000 person-years in patients with GERD was 9.7 and 8.3 in those without GERD; the age-adjusted and sex-adjusted HR was 1.17 (95% confidence interval, 1.11-1.23). This association between GERD and LDO was more pronounced among younger individuals (HR, 1.20 for patients 40 to 59-y old; HR, 1.12 for patients 60 to 79-y old) and among men (HR, 1.20 for men; HR, 1.14 for women). Patients with GERD had a higher risk of LDO than those without GERD, irrespective of history of proton-pump inhibitor use. In the sensitivity analysis, GERD patients with esophagitis had a higher risk of LDO than those without esophagitis. CONCLUSIONS: Our findings suggest that GERD is associated with an increased risk of subsequent LDO and that this effect is more pronounced among adults aged 40 to 59-years old and men.
Full Text
https://insights.ovid.com/crossref?an=00004836-201904000-00012
DOI
10.1097/MCG.0000000000001005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Jaesang(고재상) ORCID logo https://orcid.org/0000-0002-3011-7213
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Rim, Tyler Hyungtaek(임형택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170320
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