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Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy

Authors
 Xingshu Li  ;  Huanhuan Fan  ;  Tian Guo  ;  Huarong Bai  ;  Nahyun Kwon  ;  Kwang H. Kim  ;  Sungsook Yu  ;  Yejin Cho  ;  Hyunji Kim  ;  Ki Taek Nam  ;  Juyoung Yoon  ;  Xiao-Bing Zhang  ;  Weihong Tan 
Citation
 ACS Nano, Vol.13(6) : 6702-6710, 2019 
Journal Title
 ACS Nano 
ISSN
 1936-0851 
Issue Date
2019
Keywords
activatable ;  nanophotosensitizer ; photodynamic therapy ; phthalocyanine ;  protein-responsive
Abstract
A major challenge in cancer treatment is the development of effective tumor-specifictherapeutic methods that have minimal side effects. Recently, a photodynamic therapy (PDT) technique using activatable photosensitizers (aPSs) has shown great potential for cancer-specific treatment. Here, we develop a sequential protein-responsive aPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. Inside the nanostructure of PcC4-MSN-O1, PcC4 shows self-quenching photoactivity. However, when PcC4-MSN-O1 sequentially reacts with telomerase and albumin, its photoactivity is dramatically turned on. Therefore, PcC4-MSN-O1 displays selective phototoxicity against cancer cells ( e.g., HeLa) over normal cells ( e.g., HEK-293). Following systemic PcC4-MSN-O1 administration, there is an obvious accumulation in HeLa tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth. Moreover, the time-modulated activation process in tumors and the relatively fast excretion of PcC4-MSN-O1 indicate its advantages in reducing potential side effects.
Full Text
https://pubs.acs.org/doi/10.1021/acsnano.9b01100
DOI
10.1021/acsnano.9b01100
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170274
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