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Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy

DC FieldValueLanguage
dc.contributor.author남기택-
dc.date.accessioned2019-07-23T06:41:42Z-
dc.date.available2019-07-23T06:41:42Z-
dc.date.issued2019-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170274-
dc.description.abstractA major challenge in cancer treatment is the development of effective tumor-specifictherapeutic methods that have minimal side effects. Recently, a photodynamic therapy (PDT) technique using activatable photosensitizers (aPSs) has shown great potential for cancer-specific treatment. Here, we develop a sequential protein-responsive aPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. Inside the nanostructure of PcC4-MSN-O1, PcC4 shows self-quenching photoactivity. However, when PcC4-MSN-O1 sequentially reacts with telomerase and albumin, its photoactivity is dramatically turned on. Therefore, PcC4-MSN-O1 displays selective phototoxicity against cancer cells ( e.g., HeLa) over normal cells ( e.g., HEK-293). Following systemic PcC4-MSN-O1 administration, there is an obvious accumulation in HeLa tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth. Moreover, the time-modulated activation process in tumors and the relatively fast excretion of PcC4-MSN-O1 indicate its advantages in reducing potential side effects.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfACS NANO-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorXingshu Li-
dc.contributor.googleauthorHuanhuan Fan-
dc.contributor.googleauthorTian Guo-
dc.contributor.googleauthorHuarong Bai-
dc.contributor.googleauthorNahyun Kwon-
dc.contributor.googleauthorKwang H. Kim-
dc.contributor.googleauthorSungsook Yu-
dc.contributor.googleauthorYejin Cho-
dc.contributor.googleauthorHyunji Kim-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorJuyoung Yoon-
dc.contributor.googleauthorXiao-Bing Zhang-
dc.contributor.googleauthorWeihong Tan-
dc.identifier.doi10.1021/acsnano.9b01100-
dc.contributor.localIdA01243-
dc.relation.journalcodeJ00005-
dc.identifier.eissn1936-086X-
dc.identifier.pmid31184131-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsnano.9b01100-
dc.subject.keywordactivatable-
dc.subject.keyword nanophotosensitizer-
dc.subject.keywordphotodynamic therapy-
dc.subject.keywordphthalocyanine-
dc.subject.keyword protein-responsive-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthor남기택-
dc.citation.volume13-
dc.citation.number6-
dc.citation.startPage6702-
dc.citation.endPage6710-
dc.identifier.bibliographicCitationACS NANO, Vol.13(6) : 6702-6710, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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