Cited 28 times in
Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial
DC Field | Value | Language |
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dc.contributor.author | 김형일 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 손태일 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 조민아 | - |
dc.contributor.author | 최서희 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 형우진 | - |
dc.date.accessioned | 2019-07-23T06:41:00Z | - |
dc.date.available | 2019-07-23T06:41:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170271 | - |
dc.description.abstract | Clinical implications of single patient classifier (SPC) and microsatellite instability (MSI) in stage II/III gastric cancer have been reported. We investigated SPC and the status of MSI and Epstein-Barr virus (EBV) as combinatory biomarkers to predict the prognosis and responsiveness of adjuvant chemotherapy for stage II/III gastric cancer. MATERIALS AND METHODS: Tumor specimens and clinical information were collected from patients enrolled in CLASSIC trial, a randomized controlled study of capecitabine plus oxaliplatin-based adjuvant chemotherapy. The results of nine-gene based SPC assay were classified as prognostication (SPC-prognosis) and prediction of chemotherapy benefit (SPC-prediction). Five quasimonomorphic mononucleotide markers were used to assess tumor MSI status. EBV-encoded small RNA in situ hybridization was performed to define EBV status. RESULTS: There were positive associations among SPC, MSI, and EBV statuses among 586 patients. In multivariate analysis of disease-free survival, SPC-prognosis [hazard ratio (HR): 1.879 (1.101-3.205), 2.399 (1.415-4.067), p=0.003] and MSI status (HR: 0.363, 95% confidence interval: 0.161-0.820, p=0.015) were independent prognostic factors along with age, Lauren classification, TNM stage, and chemotherapy. Patient survival of SPC-prognosis was well stratified regardless of EBV status and in microsatellite stable (MSS) group, but not in MSI-high group. Significant survival benefit from adjuvant chemotherapy was observed by SPC-Prediction in MSS and EBV-negative gastric cancer. CONCLUSION: SPC, MSI, and EBV statuses could be used in combination to predict the prognosis and responsiveness of adjuvant chemotherapy for stage II/III gastric cancer. © Copyright: Yonsei University College of Medicine 2019. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Chul Kyu Roh | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Seohee Choi | - |
dc.contributor.googleauthor | Won Jun Seo | - |
dc.contributor.googleauthor | Minah Cho | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Taeil Son | - |
dc.contributor.googleauthor | Hyoung-Il Kim | - |
dc.contributor.googleauthor | Hyeseon Kim | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.3349/ymj.2019.60.2.132 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01998 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A05418 | - |
dc.contributor.localId | A05052 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 30666834 | - |
dc.subject.keyword | EBV | - |
dc.subject.keyword | Gastriccancer | - |
dc.subject.keyword | microsatelliteinstability | - |
dc.subject.keyword | singlepatientclassifier | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | 김형일 | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.contributor.affiliatedAuthor | 손태일 | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.contributor.affiliatedAuthor | 조민아 | - |
dc.contributor.affiliatedAuthor | 최서희 | - |
dc.contributor.affiliatedAuthor | 최윤영 | - |
dc.contributor.affiliatedAuthor | 허용민 | - |
dc.contributor.affiliatedAuthor | 형우진 | - |
dc.citation.volume | 60 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 139 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.60(2) : 132-139, 2019 | - |
dc.identifier.rimsid | 62770 | - |
dc.type.rims | ART | - |
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