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Association between depressive symptoms trajectories and cognitive function in late middle-age and older population: results of the Korean Longitudinal Study of Ageing

 Dong-Woo Choi  ;  Kyu-Tae Han  ;  Jooeun Jeon  ;  Sung-In Jang  ;  Seung Ju Kim  ;  Eun-Cheol Park 
 SCIENTIFIC REPORTS, Vol.9(1) : 7807, 2019 
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This study investigated the association between depressive symptoms and cognitive function according to four different trajectories of depressive symptoms in the late middle-aged and older South Korean population. Panel data from the Korean Longitudinal Study of Ageingwere analyzed. We used latent class trajectory models to identify four trajectories of depressive symptoms. We performed linear mixed-effects regression analysis to assess associations between depressive-symptom trajectories and MMSE scores. Of 4,374 participants, 18.4%, 4.9%, 55.2%, and 21.5% were classified as having a low, increasing, moderate declining, and high depressive-symptom trajectory, respectively. Individuals with an increasing trajectory (β = -0.729, P ≤ 0.001), moderate trajectory (β = -0.278, P = 0.003), and high trajectory (β = -1.605, P ≤ 0.001) had lower MMSE scores compared with those in the low trajectory group. These relationships were particularly strong among women; individuals who were physically inactive; those who were separated, divorced, or single; and those with hypertension or cerebrovascular disease. Each trajectory group for depressive symptoms was associated with cognitive decline. Moreover, female, physically inactive, and single individuals, as well as those with hypertension and cerebrovascular disease should be particularly mindful of their mental and physical health to prevent cognitive decline.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Jang, Sung In(장성인) ORCID logo https://orcid.org/0000-0002-0760-2878
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