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Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false-belief reasoning performance in healthy young Korean volunteers

 Hae Won Kim  ;  Jee In Kang  ;  Suk Kyoon An  ;  Se Joo Kim 
 CNS Neuroscience & Therapeutics, Vol.25(4) : 519-526, 2019 
Journal Title
 CNS Neuroscience & Therapeutics 
Issue Date
emotion recognition ;  false-belief reasoning ;  oxytocin receptor gene ;  resilience ; theory of mind
AIMS: A growing body of literature has indicated that oxytocin is associated with several domains of social cognition and behavior. Nevertheless, the effects of oxytocin receptor gene (OXTR) polymorphisms on social phenotypes remain unclear. Therefore, we aimed to explore the genetic influence of OXTR variants on social cognition (social perception and theory of mind) and resilience in healthy individuals. METHODS: We examined the influence of 10 common OXTR variants on social cognitive abilities, including facial emotion recognition and theory of mind, and trait resilience in 264 unrelated, healthy participants. RESULTS: We found a significant association between the A-C haplotype at rs237887-rs2268490 and facial affect recognition. In addition, the single marker rs2254298 was significantly associated with participants' scores on the Connor-Davidson Resilience Scale. In contrast, variations in OXTR did not affect participants' performance on the false-belief reasoning task. CONCLUSIONS: Single makers or haplotypes at OXTR may contribute to individual differences in facial emotion recognition and psychological resilience.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Hae Won(김혜원) ORCID logo https://orcid.org/0000-0002-9321-8361
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
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