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RNA-sequencing Profiles of Cell Cycle-Related Genes Upregulated during the G2-Phase in Giardia lamblia

Authors
 Juri Kim  ;   Mee Young Shin  ;  Soon-Jung Park 
Citation
 Korean Journal of Parasitology, Vol.57(2) : 185-189, 2019 
Journal Title
 Korean Journal of Parasitology 
ISSN
 0023-4001 
Issue Date
2019
Keywords
G2-phase ;  Giardia lamblia ; RNA-sequence ;  cell cycle
Abstract
To identify the component(s) involved in cell cycle control in the protozoan Giardia lamblia, cells arrested at the G1/S- or G2-phase by treatment with nocodazole and aphidicolin were prepared from the synchronized cell cultures. RNA-sequencing analysis of the 2 stages of Giardia cell cycle identified several cell cycle genes that were up-regulated at the G2-phase. Transcriptome analysis of cells in 2 distinct cellcycle stages of G. lamblia confirmed previously reported components of cell cycle (PcnA, cyclin B, and CDK) and identified additional cellcycle components (NEKs, Mad2, spindle pole protein, and CDC14A). This result indicates that the cell cycle machinery operates in this protozoan, one of the earliest diverging eukaryotic lineages.
Files in This Item:
T201901879.pdf Download
DOI
10.3347/kjp.2019.57.2.185
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ju Ri(김주리) ORCID logo https://orcid.org/0000-0001-8270-7584
Park, Soon Jung(박순정) ORCID logo https://orcid.org/0000-0002-0423-1944
Shin, Mee Young(신미영) ORCID logo https://orcid.org/0000-0003-3676-2683
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170215
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