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[18F]Aryl fluorides from hypervalent iodine compounds

Authors
 Chun, Joong-Hyun  ;  Son, Jeongmin  ;  Park, Jun Young  ;  Yun, Mijin 
Citation
 Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.3(1) : 3-14, 2017 
Journal Title
 Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지) 
ISSN
 2384-1583 
Issue Date
2017
Keywords
fluorine-18 ; aromatic fluorination ; hypervalent iodine ; PET ; radiotracer
Abstract
Nucleophilic aromatic fluorination has been one of the most explored methods in fluorin-18 based radiochemistry. Unlike electrophilic [18F] [18F] fluorination methods, no-carrier-added nucleophilic radiofluorination with cyclotron-produced [18F] [18F] fluoride ion offers better specific radioactivity which is essential aspect to obtain good quality images from positron emission tomography. Contrary to amenable aliphatic radiofluorination, the development of reliable aromatic [18F] [18F] fluorination methods has been pursued by many research groups; however, no viable method has yet been established. Recently, hypervalent iodine compound draws increasing attention as versatile radiolabeling precursor for various [18F] [18F] fluoroarenes, since it bears the capacity to introduce fluorine-18 either on electron-deficient or electron-rich aryl ring with enhanced regiospecificity. Other classes of hypervalent iodine congeners often utilized in radiochemistry are iodylarenes, iodonium ylides, and spirocyclic iodonium ylides. Recently developed spirocyclic iodonium ylides have already been avidly employed to provide various [18F] [18F] aryl fluorides with high labeling efficiency. This metal-free protocol would afford efficient routes, replacing the traditional approaches to [18F] [18F] fluoroarenes, from prosthetic labeling synthons to complex PET radiotracers.
Files in This Item:
T999901564.pdf Download
DOI
10.22643/JRMP.2017.3.1.3
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Young(박준영) ORCID logo https://orcid.org/0000-0003-3403-2767
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170142
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