844 695

Cited 0 times in

[18F]Aryl fluorides from hypervalent iodine compounds

 Chun, Joong-Hyun  ;  Son, Jeongmin  ;  Park, Jun Young  ;  Yun, Mijin 
 Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.3(1) : 3-14, 2017 
Journal Title
Journal of Radiopharmaceuticals and Molecular Probes(대한방사성의약품학회지)
Issue Date
fluorine-18 ; aromatic fluorination ; hypervalent iodine ; PET ; radiotracer
Nucleophilic aromatic fluorination has been one of the most explored methods in fluorin-18 based radiochemistry. Unlike electrophilic [18F]
fluorination methods, no-carrier-added nucleophilic radiofluorination with cyclotron-produced [18F]
fluoride ion offers better specific radioactivity which is essential aspect to obtain good quality images from positron emission tomography. Contrary to amenable aliphatic radiofluorination, the development of reliable aromatic [18F]
fluorination methods has been pursued by many research groups; however, no viable method has yet been established. Recently, hypervalent iodine compound draws increasing attention as versatile radiolabeling precursor for various [18F]
fluoroarenes, since it bears the capacity to introduce fluorine-18 either on electron-deficient or electron-rich aryl ring with enhanced regiospecificity. Other classes of hypervalent iodine congeners often utilized in radiochemistry are iodylarenes, iodonium ylides, and spirocyclic iodonium ylides. Recently developed spirocyclic iodonium ylides have already been avidly employed to provide various [18F]
aryl fluorides with high labeling efficiency. This metal-free protocol would afford efficient routes, replacing the traditional approaches to [18F]
fluoroarenes, from prosthetic labeling synthons to complex PET radiotracers.
Files in This Item:
T999901564.pdf Download
Appears in Collections:
6. Others (기타) > Severance Hospital (세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Young(박준영) ORCID logo https://orcid.org/0000-0003-3403-2767
Yun, Mijin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.