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Treatment response to intravitreal bevacizumab in small pigmented choroidal lesions with subretinal fluid

Authors
 Junwon Lee  ;  Hee Jung Kwon  ;  Min Kim  ;  Christopher Seungkyu Lee  ;  Sung Chul Lee 
Citation
 BMC OPHTHALMOLOGY, Vol.19(1) : 103, 2019 
Journal Title
 BMC OPHTHALMOLOGY 
Issue Date
2019
MeSH
Adult ; Aged ; Angiogenesis Inhibitors/administration & dosage* ; Bevacizumab/administration & dosage* ; Choroid Neoplasms/therapy* ; Choroidal Neovascularization/drug therapy ; Female ; Humans ; Hyperthermia, Induced/methods* ; Intravitreal Injections ; Male ; Middle Aged ; Retrospective Studies ; Subretinal Fluid ; Young Adult
Keywords
Bevacizumab ; Melanoma ; Small pigmented choroidal lesion ; Subfoveal fluid ; Transpupillary thermotherapy
Abstract
BACKGROUND: To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigate prognostic value of the therapeutic response in future tumor growth. METHODS: Retrospective chart review of 19 patients, who were diagnosed with choroidal neovascularization (CNV)-free small pigmented choroidal lesions and treated with IVB and/or TTT, was performed. RESULTS: Complete resolution of SFF was achieved in two eyes (2/14; 14.3%) after IVB, and in three eyes (3/4; 75%) after TTT. Best corrected visual acuity was improved in two eyes (2/9; 22%) after IVB, and in three eyes (3/4; 75%) after TTT. Among five patients who underwent TTT after IVB, four patients (4/5; 80%) demonstrated additional advantage. All IVBs could not reduce tumor sizes. Rather, tumor growth was detected in seven out of 14 eyes (7/14; 50%) that underwent IVB. None of the patients who underwent TTT showed tumor growth. The lack of treatment response to IVB was suggestive of malignancy, as most small pigmented lesions that had no response to IVB showed tumor growth (86%, p = 0.010). CONCLUSION: IVB was not effective in reducing tumor size and subfoveal fluid in small pigmented choroidal lesions. Therapeutic response to IVB can be used as an indicator between melanoma and nevus in small pigmented choroidal lesion.
Files in This Item:
T201901751.pdf Download
DOI
10.1186/s12886-019-1108-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170060
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