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Lessons Learned From GWAS of Asthma

Authors
 Kyung Won Kim  ;  Carole Ober 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.11(2) : 170-187, 2019 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2019
Keywords
Asthma ; genome-wide association study
Abstract
Asthma is a common complex disease of the airways. Genome-wide association studies (GWASs) of asthma have identified many risk alleles and loci that have been replicated in worldwide populations. Although the risk alleles identified by GWAS have small effects and explain only a small portion of prevalence, the discovery of asthma loci can provide an understanding of its genetic architecture and the molecular pathways involved in disease pathogenesis. These discoveries can translate into advances in clinical care by identifying therapeutic targets, preventive strategies and ultimately approaches for personalized medicine. In this review, we summarize results from GWAS of asthma from the past 10 years and the insights gleaned from these discoveries.
Files in This Item:
T201901520.pdf Download
DOI
10.4168/aair.2019.11.2.170
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169913
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