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In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach

Authors
 Xingshu Li  ;  Sungsook Yu  ;  Yoonji Lee  ;  Tian Guo  ;  Nahyun Kwon  ;  Dayoung Lee  ;  Su Cheong Yeom  ;  Yejin Cho  ;  Gyoungmi Kim  ;  Jian-Dong Huang  ;  Sun Choi  ;  Ki Taek Nam  ;  Juyoung Yoon 
Citation
 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.141(3) : 1366-1372, 2019 
Journal Title
 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 
ISSN
 0002-7863 
Issue Date
2019
Abstract
Albumin is a promising candidate as a biomarker for potential disease diagnostics and has been extensively used as a drug delivery carrier for decades. In these two directions, many albumin-detecting probes and exogenous albumin-based nanocomposite delivery systems have been developed. However, there are only a few cases demonstrating the specific interactions of exogenous probes with albumin in vivo, and nanocomposite delivery systems usually suffer from tedious fabrication processes and potential toxicity of the complexes. Herein, we demonstrate a facile "one-for-all" switchable nanotheranostic (NanoPcS) for both albumin detection and cancer treatment. In particular, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, is confirmed using an inducible transgenic mouse system. Fluorescence imaging and antitumor tests on different tumor models suggest that NanoPcS has superior tumor-targeting ability and the potential for time-modulated, activatable photodynamic therapy.
Full Text
https://pubs.acs.org/doi/10.1021/jacs.8b12167
DOI
10.1021/jacs.8b12167
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169835
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