Cited 146 times in
In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2019-07-11T03:05:32Z | - |
dc.date.available | 2019-07-11T03:05:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169835 | - |
dc.description.abstract | Albumin is a promising candidate as a biomarker for potential disease diagnostics and has been extensively used as a drug delivery carrier for decades. In these two directions, many albumin-detecting probes and exogenous albumin-based nanocomposite delivery systems have been developed. However, there are only a few cases demonstrating the specific interactions of exogenous probes with albumin in vivo, and nanocomposite delivery systems usually suffer from tedious fabrication processes and potential toxicity of the complexes. Herein, we demonstrate a facile "one-for-all" switchable nanotheranostic (NanoPcS) for both albumin detection and cancer treatment. In particular, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, is confirmed using an inducible transgenic mouse system. Fluorescence imaging and antitumor tests on different tumor models suggest that NanoPcS has superior tumor-targeting ability and the potential for time-modulated, activatable photodynamic therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Xingshu Li | - |
dc.contributor.googleauthor | Sungsook Yu | - |
dc.contributor.googleauthor | Yoonji Lee | - |
dc.contributor.googleauthor | Tian Guo | - |
dc.contributor.googleauthor | Nahyun Kwon | - |
dc.contributor.googleauthor | Dayoung Lee | - |
dc.contributor.googleauthor | Su Cheong Yeom | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Gyoungmi Kim | - |
dc.contributor.googleauthor | Jian-Dong Huang | - |
dc.contributor.googleauthor | Sun Choi | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Juyoung Yoon | - |
dc.identifier.doi | 10.1021/jacs.8b12167 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J01769 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.pmid | 30565924 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/jacs.8b12167 | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | 남기택 | - |
dc.citation.volume | 141 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1366 | - |
dc.citation.endPage | 1372 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.141(3) : 1366-1372, 2019 | - |
dc.identifier.rimsid | 62786 | - |
dc.type.rims | ART | - |
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