Cited 12 times in
Association of white blood cell count with breast cancer burden varies according to menopausal status, body mass index, and hormone receptor status: a case-control study
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 이지원 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2019-07-11T03:04:25Z | - |
dc.date.available | 2019-07-11T03:04:25Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169832 | - |
dc.description.abstract | Breast cancer is a heterogeneous disease that among Korean women has a peak incidence in the perimenopausal period. The full epidemiological characteristics of breast cancer in Korean women are not yet properly understood. We investigated whether white blood cell (WBC) is related to breast cancer burden according to estrogen receptor (ER) and progesterone receptor (PR) status in the context of body mass index and menopausal status. We conducted a large case-control study and compared WBC counts between patients with breast cancer (N = 4,402) and propensity score-matched controls (N = 4,402) selected from the Korean National Health and Nutrition Examination Survey (KNHANES). We stratified the study sample by ER/PR status, menopausal status, and body mass index and assessed the association between WBC count and breast cancer burden using multinomial logistic regression. Compared with controls, non-obese patients with ER+/PR+ breast cancer had significantly higher WBC counts regardless of menopausal status (OR 1.293 95% CI 1.139-1.363, p < 0.001 in premenopausal and OR 1.049 95% CI 1.019-1.295, p = 0.023 in postmenopausal). There was no relationship between WBC count and ER+/PR+ breast cancer among premenopausal obese women. Furthermore, premenopausal non-obese women and postmenopausal obese women with ER+/PR+ breast cancer had higher WBC counts than those with ER-/PR- breast cancer. Further larger-scale prospective cohort studies are warranted to determine these associations in the future. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association of white blood cell count with breast cancer burden varies according to menopausal status, body mass index, and hormone receptor status: a case-control study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Ji Won Lee | - |
dc.contributor.googleauthor | Seho Park | - |
dc.identifier.doi | 10.1038/s41598-019-42234-6 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A03203 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 30962496 | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 박세호 | - |
dc.contributor.affiliatedAuthor | 이지원 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5762 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : 5762, 2019 | - |
dc.identifier.rimsid | 62221 | - |
dc.type.rims | ART | - |
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