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High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway

Authors
 Hyuk Moon  ;  Kyungjoo Cho  ;  Sunyeong Shin  ;  Do Young Kim  ;  Kwang-Hyub Han  ;  Simon Weonsang Ro 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.20(3) : E581, 2019 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2019
MeSH
Animals ; Carcinoma, Hepatocellular/metabolism* ; Humans ; Liver Cirrhosis/metabolism* ; Liver Neoplasms/metabolism* ; Reactive Oxygen Species/metabolism ; Signal Transduction
Keywords
cirrhosis ; cytokines ; genetic instability ; hepatocellular carcinoma ; inflammation ; reactive oxygen species ; regeneration
Abstract
Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.
Files in This Item:
T201900953.pdf Download
DOI
10.3390/ijms20030581
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Ro, Simon Weonsang(노원상) ORCID logo https://orcid.org/0000-0003-2187-3698
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169817
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