0 99

Cited 0 times in

Population pharmacokinetic model of levetiracetam in Korean neonates with seizures

Authors
 Yun Seob Jung  ;  Soon Min Lee  ;  Min Soo Park  ;  Kyungsoo Park 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, Vol.56(5) : 217-223, 2018 
Journal Title
 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 
ISSN
 0946-1965 
Issue Date
2018
MeSH
Age Factors ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/blood ; Anticonvulsants/pharmacokinetics* ; Drug Dosage Calculations ; Drug Monitoring ; Female ; Hospitals, Pediatric ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Levetiracetam ; Male ; Metabolic Clearance Rate ; Models, Biological* ; Piracetam/administration & dosage ; Piracetam/adverse effects ; Piracetam/analogs & derivatives* ; Piracetam/blood ; Piracetam/pharmacokinetics ; Republic of Korea ; Retrospective Studies ; Seizures/blood ; Seizures/diagnosis ; Seizures/drug therapy*
Abstract
OBJECTIVE: This study was conducted to develop a population pharmacokinetic (PK) model of levetiracetam in Korean neonates with seizures. MATERIALS AND METHODS: Data were obtained from a retrospective study of 18 neonates with seizures admitted to the Neonatal Intensive Care Unit (NICU) of Severance Children's Hospital for the period of from 2013 to 2015. Sampling and dosing times were recorded by clinical research coordinators on case report forms. Demographic factors and laboratory results were tested as potential covariates for PK parameters. Model development was performed within a mixed-effect modeling framework using NONMEM. RESULTS: With a one-compartment model with first-order elimination chosen as a basic PK model based on theory-based allometric relationships, postmenstrual age and serum creatinine were found to have significant influences on clearance (CL). Typical parameter estimates of the final PK model obtained, evaluated at covariate medians, were 1.08 L/kg for volume of distribution (V) and 0.073 L/h/kg (= 1.23 mL/min/kg) for CL, illustrating that V in Korean neonates is a little larger than in Western population while CL is similar. CONCLUSION: A population PK model of levetiracetam for Korean neonates with seizures was developed in this study. The result of this study can be used as a basis to develop an optimal dosage regimen in Korean neonates with seizures.
Full Text
https://www.dustri.com/nc/article-response-page.html?artId=16597&doi=
DOI
10.5414/CP203058
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyungsoo(박경수) ORCID logo https://orcid.org/0000-0002-6972-1143
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169794
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse