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Cancer Cachexia in Pancreatic Cancer Patients: Recent Advances and New Therapeutic Approach

Authors
 Sang Hoon Lee  ;  Moon Jae Chung 
Citation
 Journal of Digestive Cancer Reports, Vol.3(2) : 61-69, 2015 
Journal Title
 Journal of Digestive Cancer Reports 
ISSN
 2288-1581 
Issue Date
2015
Keywords
Anorexia-cachexia syndrome ; Pancreatic cancer cachexia ; Pancreatic adenocarcinoma
Abstract
About 80% of all pancreatic cancer patients suffer from a wasting syndrome defined as the cancer cachexia characterized by abnormally low weight, weakness, and loss of skeletal muscle mass, which directly impacts physical activity, quality of life and overall survival. Over the past decades, we have gained new insights into the underlying mechanism of cachexia associated with pancreatic cancer. The aim of this review was to explore recent findings about cancer cachexia pathophysiology and describe the current pharmacologic approach. Pancreatic cancer cachexia is a multifactorial syndrome mediated by mechanical factors, inflammatory cytokines, neuropeptides, hormones and tumor-derived factors. The treatment of cancer cachexia remains controversial but is currently an active area of research. Several new targeted drugs are under investigation, and we hope to open a new prospect in the management of cancer cachexia in the future.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hoon(이상훈B) ORCID logo https://orcid.org/0000-0002-3619-4340
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169762
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