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Cancer Cachexia in Pancreatic Cancer Patients: Recent Advances and New Therapeutic Approach
DC Field | Value | Language |
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dc.contributor.author | 이상훈B | - |
dc.contributor.author | 정문재 | - |
dc.date.accessioned | 2019-07-10T01:00:32Z | - |
dc.date.available | 2019-07-10T01:00:32Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2288-1581 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169762 | - |
dc.description.abstract | About 80% of all pancreatic cancer patients suffer from a wasting syndrome defined as the cancer cachexia characterized by abnormally low weight, weakness, and loss of skeletal muscle mass, which directly impacts physical activity, quality of life and overall survival. Over the past decades, we have gained new insights into the underlying mechanism of cachexia associated with pancreatic cancer. The aim of this review was to explore recent findings about cancer cachexia pathophysiology and describe the current pharmacologic approach. Pancreatic cancer cachexia is a multifactorial syndrome mediated by mechanical factors, inflammatory cytokines, neuropeptides, hormones and tumor-derived factors. The treatment of cancer cachexia remains controversial but is currently an active area of research. Several new targeted drugs are under investigation, and we hope to open a new prospect in the management of cancer cachexia in the future. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Journal of Digestive Cancer Reports | - |
dc.publisher | Journal of Digestive Cancer Reports | - |
dc.relation.isPartOf | Journal of Digestive Cancer Reports | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Cancer Cachexia in Pancreatic Cancer Patients: Recent Advances and New Therapeutic Approach | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.localId | A05737 | - |
dc.contributor.localId | A03602 | - |
dc.relation.journalcode | J03296 | - |
dc.subject.keyword | Anorexia-cachexia syndrome | - |
dc.subject.keyword | Pancreatic cancer cachexia | - |
dc.subject.keyword | Pancreatic adenocarcinoma | - |
dc.contributor.alternativeName | Lee, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 이상훈B | - |
dc.contributor.affiliatedAuthor | 정문재 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 61 | - |
dc.citation.endPage | 69 | - |
dc.identifier.bibliographicCitation | Journal of Digestive Cancer Reports, Vol.3(2) : 61-69, 2015 | - |
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