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Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation

 Hye-Jin Kim  ;  Shin-Ae Kang  ;  Tai-Soon Yong  ;  Myeong-Heon Shin  ;  Kyu-Jae Lee  ;  Gab-Man Park  ;  Uktamjon Suvonkulov  ;  Hak Sun Yu 
 EXPERIMENTAL PARASITOLOGY, Vol.198 : 63-70, 2019 
Journal Title
Issue Date
Airway Resistance/drug effects* ; Animals ; Bronchoalveolar Lavage Fluid/cytology* ; Bronchoalveolar Lavage Fluid/immunology ; CD4-Positive T-Lymphocytes/drug effects ; Cyst Fluid/chemistry* ; Cyst Fluid/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Echinococcus granulosus/chemistry* ; Eosinophils/drug effects ; Female ; Host-Parasite Interactions/immunology ; Hypersensitivity/drug therapy* ; Hypersensitivity/immunology ; Inflammation/drug therapy ; Interleukin-4/immunology ; Lymph Nodes/immunology ; Mice ; Mice, Inbred C57BL ; Sheep ; Specific Pathogen-Free Organisms ; Spleen/immunology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Th2 Cells/immunology
Allergic airway inflammation ; Cystic fluid ; Echinococcus granulosus ; Treg cell
Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4+CD25+Foxp3+T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4+CD4+ T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.
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1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Myeong Heon(신명헌) ORCID logo https://orcid.org/0000-0001-8207-6110
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
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