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Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation

DC Field Value Language
dc.contributor.author신명헌-
dc.contributor.author용태순-
dc.date.accessioned2019-05-29T05:10:08Z-
dc.date.available2019-05-29T05:10:08Z-
dc.date.issued2019-
dc.identifier.issn0014-4894-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169439-
dc.description.abstractPrevious studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4+CD25+Foxp3+T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4+CD4+ T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfEXPERIMENTAL PARASITOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAirway Resistance/drug effects*-
dc.subject.MESHAnimals-
dc.subject.MESHBronchoalveolar Lavage Fluid/cytology*-
dc.subject.MESHBronchoalveolar Lavage Fluid/immunology-
dc.subject.MESHCD4-Positive T-Lymphocytes/drug effects-
dc.subject.MESHCyst Fluid/chemistry*-
dc.subject.MESHCyst Fluid/immunology-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEchinococcus granulosus/chemistry*-
dc.subject.MESHEosinophils/drug effects-
dc.subject.MESHFemale-
dc.subject.MESHHost-Parasite Interactions/immunology-
dc.subject.MESHHypersensitivity/drug therapy*-
dc.subject.MESHHypersensitivity/immunology-
dc.subject.MESHInflammation/drug therapy-
dc.subject.MESHInterleukin-4/immunology-
dc.subject.MESHLymph Nodes/immunology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHSheep-
dc.subject.MESHSpecific Pathogen-Free Organisms-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHT-Lymphocytes, Regulatory/drug effects-
dc.subject.MESHT-Lymphocytes, Regulatory/immunology-
dc.subject.MESHTh2 Cells/immunology-
dc.titleTherapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Tropica Medicine (열대의학교실)-
dc.contributor.googleauthorHye-Jin Kim-
dc.contributor.googleauthorShin-Ae Kang-
dc.contributor.googleauthorTai-Soon Yong-
dc.contributor.googleauthorMyeong-Heon Shin-
dc.contributor.googleauthorKyu-Jae Lee-
dc.contributor.googleauthorGab-Man Park-
dc.contributor.googleauthorUktamjon Suvonkulov-
dc.contributor.googleauthorHak Sun Yu-
dc.identifier.doi10.1016/j.exppara.2019.02.003-
dc.contributor.localIdA02099-
dc.contributor.localIdA02424-
dc.relation.journalcodeJ00875-
dc.identifier.eissn1090-2449-
dc.identifier.pmid30763570-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0014489418304910-
dc.subject.keywordAllergic airway inflammation-
dc.subject.keywordCystic fluid-
dc.subject.keywordEchinococcus granulosus-
dc.subject.keywordTreg cell-
dc.contributor.alternativeNameShin, Myeong Heon-
dc.contributor.affiliatedAuthor신명헌-
dc.contributor.affiliatedAuthor용태순-
dc.citation.volume198-
dc.citation.startPage63-
dc.citation.endPage70-
dc.identifier.bibliographicCitationEXPERIMENTAL PARASITOLOGY, Vol.198 : 63-70, 2019-
dc.identifier.rimsid62531-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers

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