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Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia

Authors
 Matthew G. Varga  ;  Hui Cai  ;  Tim Waterboer  ;  Gwen Murphy  ;  Taichi Shimazu  ;  Phil R. Taylor  ;  You-Lin Qiao  ;  Sue K. Park  ;  Keun-Young Yoo  ;  Sun Ha Jee  ;  Eo Rin Cho  ;  Jeongseon Kim  ;  Christian C. Abnet  ;  Shoichiro Tsugane  ;  Qiuyin Cai  ;  Wei Zheng  ;  Michael Pawlita  ;  Xiao-Ou Shu  ;  Meira Epplein 
Citation
 DIGESTIVE DISEASES AND SCIENCES, Vol.63(10) : 2765-2772, 2018 
Journal Title
 DIGESTIVE DISEASES AND SCIENCES 
ISSN
 0163-2116 
Issue Date
2018
MeSH
Antigens, Viral/analysis* ; Case-Control Studies ; Epstein-Barr Virus Infections*/diagnosis ; Epstein-Barr Virus Infections*/epidemiology ; Female ; Herpesvirus 4, Human/immunology* ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Risk Assessment ; Serologic Tests/methods ; Stomach Neoplasms*/epidemiology ; Stomach Neoplasms*/immunology ; Tumor Virus Infections/epidemiology
Keywords
Epstein–Barr virus ; Gastric cancer ; Multiplex serology
Abstract
BACKGROUND: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking. METHODS: We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea. RESULTS: The prevalence of EBV sero-positivity was universal with the exception of one sero-negative individual, and the highest titers of the EBV antigens VCA (OR 0.95, 95% CI 0.78-1.17), EBNA (OR 0.88, 95% CI 0.72-1.08), EA (OR 0.97, 95% CI 0.79-1.19), and ZEBRA (OR 0.87, 95% CI 0.71-1.07) were not associated with risk of incident gastric cancer. When we stratified these data by H. pylori status, there was no change in the association. CONCLUSIONS: Multiplex serology of the aforementioned EBV antigens in serum may not be a suitable biomarker for predicting gastric cancer risk in East Asian populations.
Full Text
https://link.springer.com/article/10.1007%2Fs10620-018-5154-9
DOI
10.1007/s10620-018-5154-9
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169426
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