Cited 11 times in
Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia
DC Field | Value | Language |
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dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2019-05-29T05:09:03Z | - |
dc.date.available | 2019-05-29T05:09:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169426 | - |
dc.description.abstract | BACKGROUND: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking. METHODS: We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea. RESULTS: The prevalence of EBV sero-positivity was universal with the exception of one sero-negative individual, and the highest titers of the EBV antigens VCA (OR 0.95, 95% CI 0.78-1.17), EBNA (OR 0.88, 95% CI 0.72-1.08), EA (OR 0.97, 95% CI 0.79-1.19), and ZEBRA (OR 0.87, 95% CI 0.71-1.07) were not associated with risk of incident gastric cancer. When we stratified these data by H. pylori status, there was no change in the association. CONCLUSIONS: Multiplex serology of the aforementioned EBV antigens in serum may not be a suitable biomarker for predicting gastric cancer risk in East Asian populations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Science + Business Media | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antigens, Viral/analysis* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Epstein-Barr Virus Infections*/diagnosis | - |
dc.subject.MESH | Epstein-Barr Virus Infections*/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Herpesvirus 4, Human/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Japan/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Serologic Tests/methods | - |
dc.subject.MESH | Stomach Neoplasms*/epidemiology | - |
dc.subject.MESH | Stomach Neoplasms*/immunology | - |
dc.subject.MESH | Tumor Virus Infections/epidemiology | - |
dc.title | Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Matthew G. Varga | - |
dc.contributor.googleauthor | Hui Cai | - |
dc.contributor.googleauthor | Tim Waterboer | - |
dc.contributor.googleauthor | Gwen Murphy | - |
dc.contributor.googleauthor | Taichi Shimazu | - |
dc.contributor.googleauthor | Phil R. Taylor | - |
dc.contributor.googleauthor | You-Lin Qiao | - |
dc.contributor.googleauthor | Sue K. Park | - |
dc.contributor.googleauthor | Keun-Young Yoo | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Eo Rin Cho | - |
dc.contributor.googleauthor | Jeongseon Kim | - |
dc.contributor.googleauthor | Christian C. Abnet | - |
dc.contributor.googleauthor | Shoichiro Tsugane | - |
dc.contributor.googleauthor | Qiuyin Cai | - |
dc.contributor.googleauthor | Wei Zheng | - |
dc.contributor.googleauthor | Michael Pawlita | - |
dc.contributor.googleauthor | Xiao-Ou Shu | - |
dc.contributor.googleauthor | Meira Epplein | - |
dc.identifier.doi | 10.1007/s10620-018-5154-9 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 29948559 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10620-018-5154-9 | - |
dc.subject.keyword | Epstein–Barr virus | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Multiplex serology | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | 지선하 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2765 | - |
dc.citation.endPage | 2772 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.63(10) : 2765-2772, 2018 | - |
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