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Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia

DC FieldValueLanguage
dc.contributor.author지선하-
dc.date.accessioned2019-05-29T05:09:03Z-
dc.date.available2019-05-29T05:09:03Z-
dc.date.issued2018-
dc.identifier.issn0163-2116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169426-
dc.description.abstractBACKGROUND: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking. METHODS: We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea. RESULTS: The prevalence of EBV sero-positivity was universal with the exception of one sero-negative individual, and the highest titers of the EBV antigens VCA (OR 0.95, 95% CI 0.78-1.17), EBNA (OR 0.88, 95% CI 0.72-1.08), EA (OR 0.97, 95% CI 0.79-1.19), and ZEBRA (OR 0.87, 95% CI 0.71-1.07) were not associated with risk of incident gastric cancer. When we stratified these data by H. pylori status, there was no change in the association. CONCLUSIONS: Multiplex serology of the aforementioned EBV antigens in serum may not be a suitable biomarker for predicting gastric cancer risk in East Asian populations.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Science + Business Media-
dc.relation.isPartOfDIGESTIVE DISEASES AND SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntigens, Viral/analysis*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEpstein-Barr Virus Infections*/diagnosis-
dc.subject.MESHEpstein-Barr Virus Infections*/epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHHerpesvirus 4, Human/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHJapan/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSerologic Tests/methods-
dc.subject.MESHStomach Neoplasms*/epidemiology-
dc.subject.MESHStomach Neoplasms*/immunology-
dc.subject.MESHTumor Virus Infections/epidemiology-
dc.titleEpstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorMatthew G. Varga-
dc.contributor.googleauthorHui Cai-
dc.contributor.googleauthorTim Waterboer-
dc.contributor.googleauthorGwen Murphy-
dc.contributor.googleauthorTaichi Shimazu-
dc.contributor.googleauthorPhil R. Taylor-
dc.contributor.googleauthorYou-Lin Qiao-
dc.contributor.googleauthorSue K. Park-
dc.contributor.googleauthorKeun-Young Yoo-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorEo Rin Cho-
dc.contributor.googleauthorJeongseon Kim-
dc.contributor.googleauthorChristian C. Abnet-
dc.contributor.googleauthorShoichiro Tsugane-
dc.contributor.googleauthorQiuyin Cai-
dc.contributor.googleauthorWei Zheng-
dc.contributor.googleauthorMichael Pawlita-
dc.contributor.googleauthorXiao-Ou Shu-
dc.contributor.googleauthorMeira Epplein-
dc.identifier.doi10.1007/s10620-018-5154-9-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00737-
dc.identifier.eissn1573-2568-
dc.identifier.pmid29948559-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10620-018-5154-9-
dc.subject.keywordEpstein–Barr virus-
dc.subject.keywordGastric cancer-
dc.subject.keywordMultiplex serology-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume63-
dc.citation.number10-
dc.citation.startPage2765-
dc.citation.endPage2772-
dc.identifier.bibliographicCitationDIGESTIVE DISEASES AND SCIENCES, Vol.63(10) : 2765-2772, 2018-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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