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Fate of Acute Heart Failure Patients With Mid-Range Ejection Fraction

Authors
 Hye Bin Gwag  ;  Ga Yeon Lee  ;  Jin-Oh Choi  ;  Hae-Young Lee  ;  Jae-Joong Kim  ;  Kyung-Kuk Hwang  ;  Shung Chull Chae  ;  Sang Hong Baek  ;  Seok-Min Kang  ;  Dong-Ju Choi  ;  Byung-Su Yoo  ;  Kye Hun Kim  ;  Hyun-Young Park  ;  Myeong-Chan Cho  ;  Byung-Hee Oh  ;  Eun-Seok Jeon 
Citation
 CIRCULATION JOURNAL, Vol.82(8) : 2071-2078, 2018 
Journal Title
CIRCULATION JOURNAL
ISSN
 1346-9843 
Issue Date
2018
Keywords
Acute heart failure ; Heart failure with mid-range ejection fraction ; Left ventricular ejection fraction
Abstract
BACKGROUND: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse.Methods and Results:Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1% were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF.

CONCLUSIONS: One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.
Files in This Item:
T201805878.pdf Download
DOI
10.1253/circj.CJ-17-1389
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169411
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