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Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

DC FieldValueLanguage
dc.contributor.author구민희-
dc.contributor.author양재문-
dc.date.accessioned2019-04-03T07:51:19Z-
dc.date.available2019-04-03T07:51:19Z-
dc.date.issued2019-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167769-
dc.description.abstractEpidermal growth factor receptor (EGFR) overexpression is common in head and neck squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been an area of keen interest in head and neck cancer research, as EGFR is potentially an integration point for convergent signaling. Despite the latest advancements in cancer diagnostics and therapeutics against EGFR, the survival rates of patients with advanced head and neck cancer remain disappointing due to anti-EGFR resistance. This review article will discuss recent multilateral efforts to discover and validate actionable strategies that involve signaling pathways in heterogenous head and neck cancer and to overcome anti-EGFR resistance in the era of precision medicine. Particularly, this review will discuss in detail the issue of cancer metabolism, which has recently emerged as a novel mechanism by which head and neck cancer may be successfully controlled according to different perspectives.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBeyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHyung Kwon Byeon-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorJaemoon Yang-
dc.identifier.doi10.1038/s12276-018-0202-2-
dc.contributor.localIdA00191-
dc.contributor.localIdA02315-
dc.contributor.localIdA02315-
dc.relation.journalcodeJ00860-
dc.identifier.eissn2092-6413-
dc.identifier.pmid30700700-
dc.contributor.alternativeNameKu, Min Hee-
dc.contributor.affiliatedAuthor구민희-
dc.contributor.affiliatedAuthor양재문-
dc.contributor.affiliatedAuthor양재문-
dc.citation.volume51-
dc.citation.number1-
dc.citation.startPage8-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.51(1) : 8, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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