0 331

Cited 12 times in

Benefit of Prolonged Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stent for Coronary Bifurcation Lesions: Results From the Coronary Bifurcation Stenting Registry II

Authors
 Woo Jin Jang  ;  Sung Gyun Ahn  ;  Young Bin Song  ;  Seung-Hyuk Choi  ;  Woo Jung Chun  ;  Ju Hyeon Oh  ;  Sung Woo Cho  ;  Bum Sung Kim  ;  Jung Han Yoon  ;  Bon-Kwon Koo  ;  Cheol Woong Yu  ;  Yang Soo Jang  ;  Seung-Jea Tahk  ;  Hyo-Soo Kim  ;  Hyeon-Cheol Gwon  ;  Sung Yun Lee  ;  Joo-Yong Hahn 
Citation
 CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.11(7) : e005849, 2018 
Journal Title
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
ISSN
 1941-7640 
Issue Date
2018
Keywords
drug-eluting stents ; incidence ; myocardial infarction ; percutaneous coronary intervention ; thrombosis
Abstract
BACKGROUND: Whether prolonged dual antiplatelet therapy (DAPT) improves clinical outcomes after percutaneous coronary intervention for coronary bifurcation lesion is uncertain.

METHODS AND RESULTS: We evaluated 2082 patients who were treated with drug-eluting stent for bifurcation lesions and were event free (no death, myocardial infarction [MI], cerebrovascular accident, stent thrombosis, or any revascularization) at 12 months after the index procedure. Patients were divided into 2 groups: DAPT ≥12-month group (n=1776) and DAPT <12-month group (n=306). Primary outcome was all-cause death or MI. At 4 years after the index procedure, death or MI occurred less frequently in the DAPT ≥12-month group than the DAPT <12-month group (2.8% versus 12.3%; adjusted hazard ratio, 0.21; 95% confidence interval, 0.13-0.35; P<0.001). After propensity score matching, incidence of death or MI was still lower in the DAPT ≥12-month group than the DAPT <12-month group (2.6% versus 12.3%; adjusted hazard ratio, 0.22; 95% confidence interval, 0.12-0.38; P<0.001). In subgroup analysis, the treatment effect of prolonged DAPT was consistent across subgroups regardless of lesion location, stenting technique, or type of used drug-eluting stent.

CONCLUSIONS: The risk of all-cause death or MI was significantly lower in the ≥12-month DAPT group than the <12-month DAPT group after percutaneous coronary intervention for bifurcation lesion using drug-eluting stent. Our results suggest that prolonged DAPT may improve long-term clinical outcomes after percutaneous coronary intervention for bifurcation lesions.

CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01642992.
Full Text
http://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.117.005849
DOI
10.1161/CIRCINTERVENTIONS.117.005849
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167626
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links