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Benefit of Prolonged Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stent for Coronary Bifurcation Lesions: Results From the Coronary Bifurcation Stenting Registry II

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dc.contributor.author장양수-
dc.date.accessioned2019-03-15T02:39:47Z-
dc.date.available2019-03-15T02:39:47Z-
dc.date.issued2018-
dc.identifier.issn1941-7640-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167626-
dc.description.abstractBACKGROUND: Whether prolonged dual antiplatelet therapy (DAPT) improves clinical outcomes after percutaneous coronary intervention for coronary bifurcation lesion is uncertain. METHODS AND RESULTS: We evaluated 2082 patients who were treated with drug-eluting stent for bifurcation lesions and were event free (no death, myocardial infarction [MI], cerebrovascular accident, stent thrombosis, or any revascularization) at 12 months after the index procedure. Patients were divided into 2 groups: DAPT ≥12-month group (n=1776) and DAPT <12-month group (n=306). Primary outcome was all-cause death or MI. At 4 years after the index procedure, death or MI occurred less frequently in the DAPT ≥12-month group than the DAPT <12-month group (2.8% versus 12.3%; adjusted hazard ratio, 0.21; 95% confidence interval, 0.13-0.35; P<0.001). After propensity score matching, incidence of death or MI was still lower in the DAPT ≥12-month group than the DAPT <12-month group (2.6% versus 12.3%; adjusted hazard ratio, 0.22; 95% confidence interval, 0.12-0.38; P<0.001). In subgroup analysis, the treatment effect of prolonged DAPT was consistent across subgroups regardless of lesion location, stenting technique, or type of used drug-eluting stent. CONCLUSIONS: The risk of all-cause death or MI was significantly lower in the ≥12-month DAPT group than the <12-month DAPT group after percutaneous coronary intervention for bifurcation lesion using drug-eluting stent. Our results suggest that prolonged DAPT may improve long-term clinical outcomes after percutaneous coronary intervention for bifurcation lesions. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01642992.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfCIRCULATION-CARDIOVASCULAR INTERVENTIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBenefit of Prolonged Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stent for Coronary Bifurcation Lesions: Results From the Coronary Bifurcation Stenting Registry II-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorWoo Jin Jang-
dc.contributor.googleauthorSung Gyun Ahn-
dc.contributor.googleauthorYoung Bin Song-
dc.contributor.googleauthorSeung-Hyuk Choi-
dc.contributor.googleauthorWoo Jung Chun-
dc.contributor.googleauthorJu Hyeon Oh-
dc.contributor.googleauthorSung Woo Cho-
dc.contributor.googleauthorBum Sung Kim-
dc.contributor.googleauthorJung Han Yoon-
dc.contributor.googleauthorBon-Kwon Koo-
dc.contributor.googleauthorCheol Woong Yu-
dc.contributor.googleauthorYang Soo Jang-
dc.contributor.googleauthorSeung-Jea Tahk-
dc.contributor.googleauthorHyo-Soo Kim-
dc.contributor.googleauthorHyeon-Cheol Gwon-
dc.contributor.googleauthorSung Yun Lee-
dc.contributor.googleauthorJoo-Yong Hahn-
dc.identifier.doi10.1161/CIRCINTERVENTIONS.117.005849-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ00539-
dc.identifier.eissn1941-7632-
dc.identifier.pmid30006330-
dc.identifier.urlhttp://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.117.005849-
dc.subject.keyworddrug-eluting stents-
dc.subject.keywordincidence-
dc.subject.keywordmyocardial infarction-
dc.subject.keywordpercutaneous coronary intervention-
dc.subject.keywordthrombosis-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthor장양수-
dc.citation.volume11-
dc.citation.number7-
dc.citation.startPagee005849-
dc.identifier.bibliographicCitationCIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.11(7) : e005849, 2018-
dc.identifier.rimsid61045-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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