36 55

Cited 0 times in

The clinical implications of FDG-PET/CT differ according to histology in advanced gastric cancer.

Authors
 Hong Jae Chon  ;  Chan Kim  ;  Arthur Cho  ;  Yoo Min Kim  ;  Su Jin Jang  ;  Bo Ok Kim  ;  Chan Hyuk Park  ;  Woo Jin Hyung  ;  Joong Bae Ahn  ;  Sung Hoon Noh  ;  Mijin Yun  ;  Sun Young Rha 
Citation
 Gastric Cancer, Vol.22(1) : 113-122, 2019 
Journal Title
 Gastric Cancer 
ISSN
 1436-3291 
Issue Date
2019
Keywords
Advanced gastric cancer ; Diffuse type ; PET/CT ; Prognostic impact ; Signet ring cell carcinoma
Abstract
BACKGROUND: The prognostic impact of preoperative 18F-FDG PET/CT in advanced gastric cancer (AGC) remains a matter of debate. This study aims to evaluate the prognostic impact of SUVmax in preoperative 18F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma. METHODS: As a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves. In addition, another 173 patients from an independent institution was assessed as an external validation set. RESULTS: In multivariate analysis, high SUVmax in preoperative 18F-FDG PET/CT of AGC was negatively correlated with disease-free survival (DFS) and overall survival (OS) in patients with diffuse type (DFS: HR 2.17, P < 0.001; OS: HR 2.47, P < 0.001) or SRC histology (DFS: HR 2.26, P = 0.005; OS: HR 2.61, P = 0.003). This negative prognostic impact was not observed in patients with intestinal type or well or moderately differentiated histology. These findings have been consistently confirmed in a validation set. The p-spline curves also showed a gradual increase in log HR as SUVmax rises only for SRC histology and for diffuse-type AGC. Finally, a novel predictive model for recurrence of AGC with diffuse type or SRC histology was generated and validated based on the preoperative SUVmax. CONCLUSIONS: Preoperative high SUVmax of AGC is a poor prognostic factor in those with diffuse type or SRC histology. This study is the first to demonstrate the differential prognostic impact of preoperative PET/CT SUVmax in AGC according to histologic subtype and provide a clue to explain previous discrepancies in the prognostic impact of preoperative PET/CT in AGC. Prospective studies are required to validate the role of preoperative SUVmax in AGC.
Files in This Item:
T201900205.pdf Download
DOI
10.1007/s10120-018-0847-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
노성훈(Noh, Sung Hoon) ORCID logo https://orcid.org/0000-0003-4386-6886
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
조응혁(Cho, Arthur Eung Hyuck) ORCID logo https://orcid.org/0000-0001-8670-2473
형우진(Hyung, Woo Jin) ORCID logo https://orcid.org/0000-0002-8593-9214
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167553
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse