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Elevated red blood cell distribution width is associated with morphometric vertebral fracture in community-dwelling older adults, independent of anemia, inflammation, and nutritional status: The Korean Urban Rural Elderly (KURE) study

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dc.contributor.author김창오-
dc.contributor.author김현창-
dc.contributor.author이유미-
dc.contributor.author최진영-
dc.contributor.author홍남기-
dc.contributor.author김현창-
dc.contributor.author이유미-
dc.contributor.author최진영-
dc.contributor.author홍남기-
dc.date.accessioned2019-03-15T02:29:15Z-
dc.date.available2019-03-15T02:29:15Z-
dc.date.issued2019-
dc.identifier.issn0171-967X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167514-
dc.description.abstractElevated red blood cell distribution width (RDW), a simple measure of red blood cell size heterogeneity, has been associated with increased mortality and morbidity in the elderly population, which might reflect systemic inflammation and malnutrition. However, whether elevated RDW is associated with prevalent morphometric vertebral fracture (VF) in older adults has not been investigated. We examined 2127 individuals (mean age 71.7 years; women 66%) from a community-based cohort. VF was defined as ≥ 25% reduction in vertebral column height using the Genant semiquantitative method. Multiple VF was defined as the presence of VF at two or more sites. The prevalence of any VF and multiple VF was 14% and 4%, respectively, increasing from the lowest to the highest RDW tertiles (12-18% and 3-6%, p for trend < 0.05 for all). RDW was positively associated with age, body mass index (BMI), malnutrition, and high-sensitivity C-reactive protein (hsCRP), whereas it was negatively associated with albumin, hemoglobin, and ferritin levels. Elevated RDW was associated with any VF [adjusted odds ratio (aOR) 1.26; p = 0.008] and multiple VF (aOR 1.36; p = 0.010) after adjustment for covariates, including age, sex, BMI, hsCRP, malnutrition, self-reported previous fracture, falls, osteoporosis, and hemoglobin and ferritin levels. The association between elevated RDW and VF remained robust in subgroups with (aOR 1.39; p = 0.048) or without anemia (aOR 1.26; p = 0.030). Elevated RDW was associated with prevalent morphometric VF in community-dwelling elderly individuals, independent of anemia, inflammation, and nutritional status.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Verlag-
dc.relation.isPartOfCALCIFIED TISSUE INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleElevated red blood cell distribution width is associated with morphometric vertebral fracture in community-dwelling older adults, independent of anemia, inflammation, and nutritional status: The Korean Urban Rural Elderly (KURE) study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorYoosik Youm-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorYumie Rhee-
dc.identifier.doi10.1007/s00223-018-0470-9-
dc.contributor.localIdA01044-
dc.contributor.localIdA01142-
dc.contributor.localIdA01142-
dc.contributor.localIdA03012-
dc.contributor.localIdA03012-
dc.contributor.localIdA04200-
dc.contributor.localIdA04200-
dc.contributor.localIdA04388-
dc.contributor.localIdA04388-
dc.contributor.localIdA01142-
dc.contributor.localIdA01142-
dc.contributor.localIdA03012-
dc.contributor.localIdA03012-
dc.contributor.localIdA04200-
dc.contributor.localIdA04200-
dc.contributor.localIdA04388-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ00425-
dc.identifier.eissn1432-0827-
dc.identifier.pmid30159752-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00223-018-0470-9-
dc.subject.keywordAging-
dc.subject.keywordBone-
dc.subject.keywordErythropoiesis-
dc.subject.keywordRDW-
dc.subject.keywordVertebral fracture-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.affiliatedAuthor김창오-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor이유미-
dc.contributor.affiliatedAuthor이유미-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor이유미-
dc.contributor.affiliatedAuthor이유미-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor홍남기-
dc.contributor.affiliatedAuthor홍남기-
dc.citation.volume104-
dc.citation.number1-
dc.citation.startPage26-
dc.citation.endPage33-
dc.identifier.bibliographicCitationCALCIFIED TISSUE INTERNATIONAL, Vol.104(1) : 26-33, 2019-
dc.identifier.rimsid45849-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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