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A novel synthetic cathinone, α-pyrrolidinopentiothiophenone (PVT), produces locomotor sensitization in rat: Implications for GSK3β connections in the nucleus accumbens core

Authors
 Hyung Shin Yoon  ;  Min Jeong Ku  ;  Wen Ting Cai  ;  Jeong-Hoon Kim 
Citation
 NEUROCHEMISTRY INTERNATIONAL, Vol.124 : 25-30, 2019 
Journal Title
 NEUROCHEMISTRY INTERNATIONAL 
ISSN
 0197-0186 
Issue Date
2019
Keywords
GSK3β ; Locomotor sensitization ; Novel psychoactive substance ; Nucleus accumbens ; α-PVT
Abstract
A novel psychoactive substance, α-pyrrolidinopentiothiophenone (α-PVT), is a structural analog to amphetamine. Recently, it has been shown that α-PVT has an abuse potential similar to psychomotor stimulants like cocaine or amphetamine. However, it has not been performed yet to determine whether α-PVT develops behavioral sensitization, a well-known phenomenon for psychomotor stimulants. In the present study, rats were first pre-exposed to either saline or α-PVT (20 mg/kg, IP) with a total of four injections in every 2-3 days of interval. Then, 2-weeks after withdrawal, locomotor activity was measured with a challenge dose (10 mg/kg, IP) of α-PVT and the nucleus accumbens core region was taken out. Similar to psychomotor stimulants, repeated administration of α-PVT produced locomotor sensitization. Further, the phosphorylation levels of GSK3β in the nucleus accumbens core were found to be decreased only in rats with sensitization developed, but not in those with acute or non-sensitized. Correlation analysis revealed that the phosphorylation levels of GSK3β have a strong negative correlation with locomotor activity only in rats with α-PVT pre-exposed, but not in those with its acute injection. These results suggest that a certain level of change in the phosphorylation levels of GSK3β in the nucleus accumbens core may involve in mediating the expression of locomotor sensitization by repeated injection of α-PVT in rats.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197018618305576
DOI
10.1016/j.neuint.2018.12.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hoon(김정훈) ORCID logo https://orcid.org/0000-0001-7095-3729
Yoon, Hyung Shin(윤형신) ORCID logo https://orcid.org/0000-0003-4389-7578
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167505
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