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Cancer Risk in Patients with Intestinal Behçet’s Disease: A Nationwide Population-Based Study

Authors
 Minkyung Han  ;  Yoon Suk Jung  ;  Won Ho Kim  ;  Jae Hee Cheon  ;  Sohee Park 
Citation
 GUT AND LIVER, Vol.12(4) : 433-439, 2018 
Journal Title
 GUT AND LIVER 
ISSN
 1976-2283 
Issue Date
2018
MeSH
Adult ; Behcet Syndrome/complications* ; Female ; Hematologic Neoplasms/epidemiology ; Hematologic Neoplasms/etiology* ; Humans ; Incidence ; Intestinal Diseases/complications* ; Male ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/etiology ; Republic of Korea/epidemiology ; Risk Factors ; Sex Factors
Keywords
Intestinal Behçet’s disease ; Neoplasms ; Population-based
Abstract
Background/Aims: The relationship between intestinal Behçet's disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with intestinal BD. Methods: Using the National Health Insurance claims records, we collected data on 365 patients who had been diagnosed with intestinal BD between 2011 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with intestinal BD in comparison with the general population were calculated. Results: Among 167 men with intestinal BD, four cases of cancer were observed; among 191 women with BD, eight cases of cancer were observed. The risk of all cancers was significantly higher in women with intestinal BD than in women of the general population (SIR, 4.27; 95% confidence interval [CI], 1.84 to 8.41). However, in men with intestinal BD, the risk of all cancers was not significantly higher than that in men of the general population (SIR, 2.08; 95% CI, 0.57 to 5.33). The risk of hematologic cancer was significantly higher in both men and women with intestinal BD than in their counterparts in the general population (SIR, 23.90; 95% CI, 2.89 to 86.32 in men; SIR, 34.47; 95% CI, 4.17 to 124.51 in women). In particular, patients with intestinal BD showed a higher risk of leukemia and myelodysplastic syndrome than the general population. Conclusions: Patients with intestinal BD demonstrated a higher risk of hematologic cancer, especially leukemia, than the general population. Furthermore, women with intestinal BD showed a higher risk of all cancers.
Files in This Item:
T201805622.pdf Download
DOI
10.5009/gnl17324
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Han, Minkyung(한민경) ORCID logo https://orcid.org/0000-0002-5011-5557
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167501
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