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아세트아미노펜 중독 환자에서 간독성 발생 예측인자들의 유용성

Other Titles
 Usefulness of Predictors for Hepatotoxicity in Acetaminophen Poisoning Patient 
Authors
 김은영  ;  정성필  ;  고동률  ;  공태영  ;  유제성  ;  좌민홍  ;  김민정 
Citation
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.16(2) : 149-156, 2018 
Journal Title
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지) 
ISSN
 1738-1320 
Issue Date
2018
Keywords
Acetaminophen ; Poisoning ; Drug-induced acute liver injury
Abstract
Purpose: The purpose of this study was to determine whether hepatotoxicity could be predicted early using biochemical markers in patients with acetaminophen (AAP) poisoning and to assess the usefulness of predictive factors for acute liver injury or hepatotoxicity. Methods: This study was a retrospective observational study involving a medical records review. The participants were patients who were admitted to the emergency department (ED) with AAP overdose at two hospitals over a 10- year period. Demographic data, age, time from ingestion to visit, initial AAP level, initial hepatic aminotransferases, and initial prothrombin time were recorded. Acute liver injury was defined as a peak serum ALT >50 U/L or double the admission value, and hepatotoxicity was defined as a peak ALT >1,000 U/L. Receiver operating characteristic curve analyses were performed to compare the prognostic performance among variables. Results: A total of 97 patients were admitted to the ED with AAP overdose, of whom 26 had acute liver injury and 6 had hepatotoxicity. Acute liver injury was associated with the time interval after taking the drug, and hepatotoxicity was associated with the initial PT and the ALT level. The scoring system proposed by the authors has a significant ability to predict both acute liver injury and hepatotoxicity. Conclusion: To predict the prognosis of AAP poisoning patients, the time interval after taking AAP was important, and initial prothrombin time and ALT level were useful tests. Also a scoring system combining variables may be useful.
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DOI
10.22537/jksct.16.2.149
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고동률(Ko, Dong Ryul) ORCID logo https://orcid.org/0000-0002-3098-2784
공태영(Kong, Tae Young) ORCID logo https://orcid.org/0000-0002-4182-7245
김민정(Kim, Min Joung) ORCID logo https://orcid.org/0000-0003-1634-5209
김은영(Kim, Eun Young) ORCID logo https://orcid.org/0000-0003-1269-0910
유제성(You, Je Sung) ORCID logo https://orcid.org/0000-0002-2074-6745
정성필(Chung, Sung Pil) ORCID logo https://orcid.org/0000-0002-3074-011X
좌민홍(Choa, Min Hong) ORCID logo https://orcid.org/0000-0003-0338-994X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167185
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