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Platelet count and 8-year incidence of diabetes: The Korean Genome and Epidemiology Study

 Jin-Young Hwang  ;  Yu-Jin Kwon  ;  Won-Jun Choi  ;  Dong-Hyuk Jung 
 Diabetes Research and Clinical Practice, Vol.143 : 301-309, 2018 
Journal Title
 Diabetes Research and Clinical Practice 
Issue Date
Cohort study ; KOGES ; Platelet count ; Type 2 DM
AIMS: The aim of this study is to investigate the effect of platelet count on the incidence of type 2 diabetes mellitus (DM) in the overall Korean adults and in participants with impaired glucose tolerance (IGT) at baseline. METHODS: A total of 7502 participants (3528 men and 3974 women) aged 40-69 years were enrolled in this study. The study population was divided into tertiles (T) of serum platelet counts. We used Cox regression to analyse the relationship between baseline platelet count and new-onset type 2 DM. RESULTS: A total of 602 (8.0%) subjects developed type 2 DM during a mean follow-up of 8.4 years. Compared to the lowest tertile, the hazard ratio (95% confidence interval [CI]) for the incidence of type 2 DM was 1.28 (1.04-1.57) for T3 after adjusting for possible confounding factors. In subjects with IGT at baseline, the hazard ratio (95% CI) for the incidence of type 2 DM in T3 compared with T1 was 1.45 (1.05-2.00) after adjusting for the same confounders. CONCLUSION: This prospective longitudinal study demonstrated that the incidence of type 2 DM increased as the serum platelet count at baseline increased within the normal range. This positive association was more prominent in subjects with IGT.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
권유진(Kwon, Yu-Jin) ORCID logo https://orcid.org/0000-0002-9021-3856
정동혁(Jung, Dong Hyuk) ORCID logo https://orcid.org/0000-0002-3411-0676
최원준(Choi, Won Jun) ORCID logo https://orcid.org/0000-0002-8233-9272
황진영(Hwang, Jin-Young) ORCID logo https://orcid.org/0000-0002-7277-2689
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