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Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Authors
 Dae-Hyun Kim  ;  Jung Bok Lee  ;  Mi-Lan Kang  ;  Ji Hwan Park  ;  Jin You  ;  SeongMi Yu  ;  Ju Young Park  ;  Seung Bae Ryu  ;  Gyeung Mi Seon  ;  Jeong-Kee Yoon  ;  Mi Hee Lee  ;  Young Min Shin  ;  Ki Dong Park  ;  Jong-Chul Park  ;  Woo Soon Jang  ;  Won Shik Kim  ;  Hak-Joon Sung 
Citation
 ACS Biomaterials Science & Engineering, Vol.4(11) : 3848-3853, 2018 
Journal Title
 ACS Biomaterials Science & Engineering 
Issue Date
2018
Keywords
cytocompatibility ; heparin coating ; microneedles ; tubular construct ; vascular anastomosis
Abstract
To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.
Full Text
https://pubs.acs.org/doi/ipdf/10.1021/acsbiomaterials.8b01097
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
김대현(Kim, Dae-Hyun)
김원식(Kim, Won Shik)
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
성학준(Sung, Hak-Joon) ORCID logo https://orcid.org/0000-0003-2312-2484
윤정기(Yoon, Jeong-Kee) ORCID logo https://orcid.org/0000-0003-0111-9911
이미희(Lee, Mi Hee) ORCID logo https://orcid.org/0000-0002-9630-7044
이정복(Lee, Jung Bok) ORCID logo https://orcid.org/0000-0001-9227-2027
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167150
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