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T2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.contributor.author김명진-
dc.contributor.author김성원-
dc.contributor.author서니은-
dc.contributor.author안중배-
dc.contributor.author임준석-
dc.date.accessioned2019-02-12T16:45:40Z-
dc.date.available2019-02-12T16:45:40Z-
dc.date.issued2018-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167128-
dc.description.abstractOBJECTIVES: To evaluate the diagnostic value of signal intensity (SI)-selected volumetry findings in T2-weighted magnetic resonance imaging (MRI) as a potential biomarker for predicting pathological complete response (pCR) to preoperative chemoradiotherapy (CRT) in patients with rectal cancer. METHODS: Forty consecutive patients with pCR after preoperative CRT were compared with 80 age- and sex-matched non-pCR patients in a case-control study. SI-selected tumor volume was measured on post-CRT T2-weighted MRI, which included voxels of the treated tumor exceeding the SI (obturator internus muscle SI + [ischiorectal fossa fat SI - obturator internus muscle SI] × 0.2). Three blinded readers independently rated five-point pCR confidence scores and compared the diagnostic outcome with SI-selected volumetry findings. The SI-selected volumetry protocol was validated in 30 additional rectal cancer patients. RESULTS: The area under the receiver-operating characteristic curve (AUC) of SI-selected volumetry for pCR prediction was 0.831, with an optimal cutoff value of 649.6 mm3 (sensitivity 0.850, specificity 0.725). The AUC of the SI-selected tumor volume was significantly greater than the pooled AUC of readers (0.707, p < 0.001). At this cutoff, the validation trial yielded an accuracy of 0.87. CONCLUSION: SI-selected volumetry in post-CRT T2-weighted MRI can help predict pCR after preoperative CRT in patients with rectal cancer. KEY POINTS: • Fibrosis and viable tumor MRI signal intensities (SIs) are difficult to distinguish. • T2 SI-selected volumetry yields high diagnostic performance for assessing pathological complete response. • T2 SI-selected volumetry is significantly more accurate than readers and non-SI-selected volumetry. • Post-chemoradiation therapy T2-weighted MRI SI-selected volumetry facilitates prediction of pathological complete response.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEuropean Radiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHColectomy*-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHNeoplasm Staging/methods*-
dc.subject.MESHPostoperative Period-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHROC Curve-
dc.subject.MESHRectal Neoplasms/diagnosis*-
dc.subject.MESHRectal Neoplasms/therapy-
dc.subject.MESHRectum/pathology*-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHTreatment Outcome-
dc.titleT2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorSungwon Kim-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorNieun Seo-
dc.contributor.googleauthorHye Jin Kim-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorJoon Seok Lim-
dc.identifier.doi10.1007/s00330-018-5520-1-
dc.contributor.localIdA00273-
dc.contributor.localIdA00426-
dc.contributor.localIdA00426-
dc.contributor.localIdA05309-
dc.contributor.localIdA05309-
dc.contributor.localIdA01874-
dc.contributor.localIdA01874-
dc.contributor.localIdA02262-
dc.contributor.localIdA02262-
dc.contributor.localIdA03408-
dc.contributor.localIdA03408-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid29858637-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00330-018-5520-1-
dc.subject.keywordDrug therapy-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordNeoadjuvant therapy-
dc.subject.keywordRectal neoplasms-
dc.subject.keywordTumor burden-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.affiliatedAuthor금웅섭-
dc.contributor.affiliatedAuthor김명진-
dc.contributor.affiliatedAuthor김명진-
dc.contributor.affiliatedAuthor김성원-
dc.contributor.affiliatedAuthor김성원-
dc.contributor.affiliatedAuthor서니은-
dc.contributor.affiliatedAuthor서니은-
dc.contributor.affiliatedAuthor안중배-
dc.contributor.affiliatedAuthor안중배-
dc.contributor.affiliatedAuthor임준석-
dc.contributor.affiliatedAuthor임준석-
dc.citation.volume28-
dc.citation.number12-
dc.citation.startPage5231-
dc.citation.endPage5240-
dc.identifier.bibliographicCitationEuropean Radiology, Vol.28(12) : 5231-5240, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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