Cited 23 times in
T2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 김성원 | - |
dc.contributor.author | 서니은 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 임준석 | - |
dc.date.accessioned | 2019-02-12T16:45:40Z | - |
dc.date.available | 2019-02-12T16:45:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167128 | - |
dc.description.abstract | OBJECTIVES: To evaluate the diagnostic value of signal intensity (SI)-selected volumetry findings in T2-weighted magnetic resonance imaging (MRI) as a potential biomarker for predicting pathological complete response (pCR) to preoperative chemoradiotherapy (CRT) in patients with rectal cancer. METHODS: Forty consecutive patients with pCR after preoperative CRT were compared with 80 age- and sex-matched non-pCR patients in a case-control study. SI-selected tumor volume was measured on post-CRT T2-weighted MRI, which included voxels of the treated tumor exceeding the SI (obturator internus muscle SI + [ischiorectal fossa fat SI - obturator internus muscle SI] × 0.2). Three blinded readers independently rated five-point pCR confidence scores and compared the diagnostic outcome with SI-selected volumetry findings. The SI-selected volumetry protocol was validated in 30 additional rectal cancer patients. RESULTS: The area under the receiver-operating characteristic curve (AUC) of SI-selected volumetry for pCR prediction was 0.831, with an optimal cutoff value of 649.6 mm3 (sensitivity 0.850, specificity 0.725). The AUC of the SI-selected tumor volume was significantly greater than the pooled AUC of readers (0.707, p < 0.001). At this cutoff, the validation trial yielded an accuracy of 0.87. CONCLUSION: SI-selected volumetry in post-CRT T2-weighted MRI can help predict pCR after preoperative CRT in patients with rectal cancer. KEY POINTS: • Fibrosis and viable tumor MRI signal intensities (SIs) are difficult to distinguish. • T2 SI-selected volumetry yields high diagnostic performance for assessing pathological complete response. • T2 SI-selected volumetry is significantly more accurate than readers and non-SI-selected volumetry. • Post-chemoradiation therapy T2-weighted MRI SI-selected volumetry facilitates prediction of pathological complete response. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chemoradiotherapy | - |
dc.subject.MESH | Colectomy* | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Neoplasm Staging/methods* | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Rectal Neoplasms/diagnosis* | - |
dc.subject.MESH | Rectal Neoplasms/therapy | - |
dc.subject.MESH | Rectum/pathology* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | T2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Sungwon Kim | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Nieun Seo | - |
dc.contributor.googleauthor | Hye Jin Kim | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.identifier.doi | 10.1007/s00330-018-5520-1 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A05309 | - |
dc.contributor.localId | A01874 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03408 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 29858637 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00330-018-5520-1 | - |
dc.subject.keyword | Drug therapy | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Neoadjuvant therapy | - |
dc.subject.keyword | Rectal neoplasms | - |
dc.subject.keyword | Tumor burden | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.contributor.affiliatedAuthor | 김성원 | - |
dc.contributor.affiliatedAuthor | 서니은 | - |
dc.contributor.affiliatedAuthor | 안중배 | - |
dc.contributor.affiliatedAuthor | 임준석 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5231 | - |
dc.citation.endPage | 5240 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.28(12) : 5231-5240, 2018 | - |
dc.identifier.rimsid | 58108 | - |
dc.type.rims | ART | - |
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